(+/-) 5-HETE LactoneCAS: 73279-37-5
MF: C20H30O2
MW: 302.5
An inhibitor and marker of 5-LO activity.

(±) 5-HETE Lactone (CAS 73279-37-5)

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Application: An inhibitor and marker of 5-LO activity
CAS Number: 73279-37-5
Molecular Weight: 302.5
Molecular Formula: C20H30O2
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* Refer to Certificate of Analysis for lot specific data (including water content).
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(±) 5-HETE Lactone is a unique marker for 5-lipoxygenase activation. (±) 5-HETE Lactone is a cyclic ester formed by acid-catalyzed nucleophilic addition of the C-5 hydroxyl to the C-1 carboxyl of (±)5-HETE. It inhibits 5-LO (5-lipoxygenase) (IC50=27 µM) from rat basophilic leukemia cells. The lactone form is several times more potent.


References

1. Kerdesky, F.A., et al. 1987. J. Med. Chem. 30: 1177-1186. PMID: 3599023

Formulation :
50 µg/ml in ethanol
Appearance :
Oil
Solubility :
Soluble in acetonitrile
Storage :
Store at -80° C
Boiling Point :
78° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
6439592
SMILES :
CCCCCC=CCC=CCC=CC=CC1CCCC(=O)O1

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Certificate of Analysis

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