Anti-PLC δ3 Antibody (E-5) is a mouse monoclonal IgG1 κ PLC δ3 antibody, cited in 1 publications, provided at 200 µg/ml
specific for an epitope mapping between amino acids 517-535 within an internal region of PLC δ3 of human origin
Anti-PLC delta 3 Antibody (E-5) is recommended for detection of PLC δ3 of mouse, rat and human origin by WB, IP, IF and ELISA
Anti-PLC delta 3 Antibody (E-5) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PLC δ3 (E-5): sc-514912.
m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PLC δ3 Antibody (E-5) for WB applications. These reagents are now offered in bundles with PLC δ3 Antibody (E-5) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
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Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
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Labware ships FedEx Ground free of charge to the contiguous US
PLC δ3 Antibody (E-5) is a high quality monoclonal PLC delta 3 antibody (also designated PLC δ3 antibody) suitable for the detection of the PLC delta 3 protein of mouse, rat and human origin. PLC δ3 Antibody (E-5) is available as both the non-conjugated anti-PLC delta 3 antibody form, as well as multiple conjugated forms of anti-PLC delta 3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Phosphoinositide-specific phospholipase C (PLC) plays a crucial role in the initiation of receptor-mediated signal transduction through the generation of the two second messengers, inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG) from phosphatidylinositol 4,5-bisphosphate. There are several mammalian PLC proteins, including PLC β1, PLC β2, PLC β3, PLC β4, PLCγ1, PLCγ2, PLC δ1, PLC δ3, PLC δ4 and PLCe. PLC δ1, a calcium signal amplifier, is activated by an atypical GTP-binding protein and functions as an effector for GTP-binding protein transglutaminase II-mediated oxytocin receptor and α1B-adrenoreceptor signaling. PLC δ1 is highly expressed in brain, heart, lung and testis and is abnormally accumulated in autopsied brains with Alzheimer′s disease (AD), suggesting that it may play a role in the pathology of AD. Both PLC δ3 and PLC δ4 contain several functional domains through which they bind calcium as a cofactor and catalyze the creation of DAG and IP3, playing an essential role in signal transduction. PLC δ4 is highly expressed in skeletal muscle and kidney tissue, as well as in corneal epithelial cells, suggesting a role in the regulation of kidney and ocular function.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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