Anti-PLC β4 Antibody (A-8) is a mouse monoclonal IgG2a κ PLC β4 antibody, cited in 6 publications, provided at 200 µg/ml
raised against amino acids 876-1115 of PLC β4 of human origin
Anti-PLC beta 4 Antibody (A-8) is recommended for detection of PLC β4 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
Anti-PLC beta 4 Antibody (A-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PLC β4 (A-8): sc-166131.
m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for PLC β4 Antibody (A-8) for WB and IHC(P) applications. These reagents are now offered in bundles with PLC β4 Antibody (A-8) (see ordering information below).
Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
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SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
PLC β4 Antibody (A-8) is a high quality monoclonal PLC beta 4 antibody (also designated PLC β4 antibody) suitable for the detection of the PLC beta 4 protein of mouse, rat and human origin. PLC β4 Antibody (A-8) is available as both the non-conjugated anti-PLC beta 4 antibody form, as well as multiple conjugated forms of anti-PLC beta 4 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Phosphoinositide-specific phospholipase C (PLC) plays a critical role in the initiation of receptor mediated signal transduction through the generation of the two second messengers, inositol 1, 4, 5-triphosphate and diacylglycerol from phosphatidylinositol 4, 5 bisphosphate. A total of eight mammalian PLC isozymes have been described (PLC β1, PLC β2, PLC β3, PLC β4, PLC γ1, PLC γ2, PLC δ1 and PLC δ2). The γ-type enzymes are unique in that they contain SH2 and SH3 domains. Moreover, the two γ-type enzymes, but not the β and δ isozymes, are subject to activation by a number of protein tyrosine kinases which associate with their SH2 domains and induce their activation by phosphoryation. In contrast, activation of PLC β1, PLC β2 and PLC β3 is mediated by the a subunits of the Gq class of heterotrimeric G proteins and by certain bg G protein subunits. The regulatory mechanisms for PLC δ1 and PLC δ2 are not yet resolved.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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