PKSI-527 is a highly selective plasma kallikrein inhibitor (Ki = 0.81 μM) which can be used for affinity purification of kalikrein. It suppresses collagen-induced arthritis in a mouse model. Additionally, PKSI-527 has been shown to synergize with NO donors producing antithrombotic effects.
1: K. Wanaka et al. Chem. Pharm. Bull. 1992 40 1814 2: M. Tada et al. Biol. Pharm. Bull. 2001 24 520 3: Y. Fujimori et al. Agents Actions 1993 39 42 4: H. Ikarugi et al. Thromb. Res. 2005 116 403
Soluble in water (5 mg/ml).
Store at -20° C
selective plasma kalikrein: Ki= 0.81 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Adams et alAdams et al. (PubMed ID 21297000) found that PKSI 527 shortened carotid artery occlusion times via inhibition of prolylcarboxypeptidase (PRCP) in mice. -SCBT Publication Review
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