PKSI-527A highly selective plasma kalikrein inhibitor that can be used for affinity purification of kalikrein

PKSI-527 (CAS 128837-71-8)

PKSI-527 | CAS 128837-71-8 is rated 5.0 out of 5 by 1.
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Synonym: trans-4-Aminomethylcyclohexanecarbonyl-phenylalanyl-4-carboxymethylanilide
Application: A highly selective plasma kalikrein inhibitor that can be used for affinity purification of kalikrein
CAS Number: 128837-71-8
Purity: ≥95%
Molecular Weight: 473.99
Molecular Formula: C25H31N3O4•HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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PKSI-527 is a highly selective plasma kallikrein inhibitor (Ki = 0.81 μM) which can be used for affinity purification of kalikrein. It suppresses collagen-induced arthritis in a mouse model. Additionally, PKSI-527 has been shown to synergize with NO donors producing antithrombotic effects.


References

1: K. Wanaka et al. Chem. Pharm. Bull. 1992 40 1814 2: M. Tada et al. Biol. Pharm. Bull. 2001 24 520 3: Y. Fujimori et al. Agents Actions 1993 39 42 4: H. Ikarugi et al. Thromb. Res. 2005 116 403

Physical State :
Solid
Solubility :
Soluble in water (5 mg/ml).
Storage :
Store at -20° C
Ki Data :
selective plasma kalikrein: Ki= 0.81 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
3035562
SMILES :
C1CC(CCC1CN)C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)NC3=CC=C(C=C3)CC(=O)O.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Adams et al Adams et al. (PubMed ID 21297000) found that PKSI 527 shortened carotid artery occlusion times via inhibition of prolylcarboxypeptidase (PRCP) in mice. -SCBT Publication Review
Date published: 2015-04-08
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