PKG inhibitor is a specific cGKI (cyclic GMP-dependent protein kinase) inhibitor. Data indicates that it does not block cyclic GMP-dependent protein kinase phosphorylation of intact histones and has been used to study Plasmodium falciparum. NMDA potentiation and GABA nitric oxide depression have been reported to be blocked by the PKG inhibitor. Other PKG inhibitors include KT5823 (sc-3534), which activates apoptotic DNA fragmentation.
Rated 5 out of
WexlerWexler, EM. et al. (PubMed 9502795) used the PKG Inhibitor to demonstrate that nitric oxide depresses GABAA receptor function via coactivation of cGMP-dependent kinase and phosphodiesterase. -SCBT Publication Review
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