PKF118-310

PKF118-310 (CAS 84-82-2)

PKF118-310 | CAS 84-82-2 is rated 5.0 out of 5 by 1.
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Synonym: Toxoflavin; Xanthothricin
Application: An inhibitor of survivin expression and antagonist of Tcf4/b-catenin signaling
CAS Number: 84-82-2
Purity: ≥98%
Molecular Weight: 193.16
Molecular Formula: C7H7N5O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

PKF118-310 is an inhibitor of survivin expression and antagonist of Tcf4/b-catenin signaling. Shown to induce apoptosis in tumor cells.

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mg/ml).
Storage :
Store at 4° C
Melting Point :
178-180° C
Boiling Point :
~276.7° C at 760 mmHg (Predicted)
Density :
~1.7 g/cm3 (Predicted)
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
Plasmodium yoelii: IC50 = 102.8 nM; Heat shock protein HSP90: IC50 = 238.1 nM (human); Plasmodium falciparum: EC5050 = 481 nM; PTP22: IC50 = 1.35 µM (human); VHR: IC50 = 1.36 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
Transport :
UN 2811, Class 6.1, Packing group III
PubChem CID :
66541
MDL Number :
MFCD00459812
SMILES :
CN1C2=NC(=O)N(C(=O)C2=NC=N1)C

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Wang et al Wang et al. (PubMed ID 26314431) found that PKF118-310 induces cycle arest of K562 cells at the S phase and inhibits cell proliferation through reducing -catenin/TCF/BCL-9 activity. -SCBT Publication Review
Date published: 2015-04-04
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