PKC zeta Pseudo-substrate inhibitor, MyristoylatedA cell-permeable form of the PKCζ isozyme pseudosubstrate inhibitory peptide

PKC ζ Pseudo-substrate inhibitor, Myristoylated

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Datasheets
Synonym: Myristoylated
Application: A cell-permeable form of the PKCζ isozyme pseudosubstrate inhibitory peptide
Purity: ≥95%
Molecular Weight: 1928.5
Molecular Formula: C90H154N30O17
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PKC ζ Pseudo-substrate inhibitor, Myristoylated (ZIP) is a cell-permeable, reversible, substrate competitive, myristoylated form of the protein kinase Cζ isozyme pseudosubstrate inhibitory peptide (sc-3098) found to inhibit an atypical type of Protein Kinase C ζ (zeta). It has been shown to also interact with PKC family isoforms and disrupt conventional PKC targeting and translocation leading to physiological memory impairment. The sequence corresponds to the pseudosubstrate region of the N-terminal regulatory domain that maintains the enzyme in an inactive form in the absence of activator. The pseudosubstrate peptide has also been shown to be a competitive inhibitor of PKCζ in neurons. This peptide was also used to demonstrate that PKC ζ is involved in the regulation of integrin-dependent adhesion and chemotaxis of intact human neutrophils.

Physical State :
Solid
Sequence :
Myr-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-OH
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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