PKC ε inhibitor peptide

5.0(1)

Alternate Names: PKCε Translocation Inhibitor Peptide; EAVSLKPT; Protein Kinase Cε Translocation Inhibitor Peptide

Application: PKC ε inhibitor peptide is selectively and reversibly inhibits the translocation of Protein Kinase C epsilon

Purity: ≥97%

Molecular Weight: 844

Molecular Formula: C₃₇H₆₅N₉O₁₃

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

* Refer to Certificate of Analysis for lot specific data (including water content).

QUICK LINKS

PKC ε inhibitor peptide is an octapeptide that selectively and reversibly inhibits the translocation of Protein Kinase C epsilon. Inhibition of PKCε translocation is relevant to the study of norepinephrine-mediated regulation of contraction in cardiomyocytes.

References

1. Johnson, J A., et al., 1996. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. The Journal of biological chemistry. 271(40): 24962-6. PMID: 8798776
2. Yedovitzky, M., et al., 1997. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells. The Journal of biological chemistry. 272(3): 1417-20. PMID: 8999804

Appearance :

Lyophilized powder

Physical State :

Solid

Sequence :

H-Glu-Ala-Val-Ser-Leu-Lys-Pro-Thr-OH

Solubility :

Soluble in water.

Storage :

Store at -20° C

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

Download SDS (MSDS)

Certificate of Analysis

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PKC ε inhibitor peptide Product Citations

See how others have used PKC ε inhibitor peptide. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 13 total

PMID: # 32781622 Jang, S.|Lee, S.|Park, H.| et al. 2020. Molecules. 25:

PMID: # 27330081 Sen, A. et al. 2016. The Journal of biological chemistry. 291: 16462-76.

PMID: # 25672459 Li, L. et al. 2015. Molecular medicine reports. 11: 4373-80.

PMID: # 24338688 2014. The Journal of biological chemistry. 289: 3148-63.

PMID: # 24806747 2014. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme. 46: 390-6.

PMID: # 25490397 2014. PloS one. 9: e113485.

PMID: # 20615477 2010. Prostaglandins & other lipid mediators. 93: 84-92.

PMID: # 20299424 2010. The Journal of pharmacology and experimental therapeutics. 333: 970-5.

PMID: # 19706599 Gayen, JR. et al. 2009. The Journal of biological chemistry. 284: 28498-509.

PMID: # 18039843 2008. Molecular and cellular biology. 28: 1007-17.

Citations 1 to 10 of 13 total

Hello, I am interested in using this PKC epsilon inhibitor in RAW 264.7 cells. Would you recommend transfecting the cells with the inhibitor/scrambled peptide, or is simple incubation with the inhibitor sufficient? Many thanks Sonia

Asked by: Son123

Thank you for your question. Since the peptide is not cell permeable, we recommend transient permeabilization with saponin at 150 µg/ml. You can find more information about the use of this peptide in these references: Yedovitzky, M., et al. 1997. J. Biol. Chem. 272, 1417. Johnson, J.A., et al. 1996. J. Biol. Chem. 271, 24962. https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&orig_db=pubmed&term=EAVSLKPT If you have any further questions, please contact our European Technical Service team. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: [email protected] or by live chat directly on our website, www.scbt.com

Answered by: Tech Service

Date published: 2017-07-05

Rated 5 out of 5 by Joy from Worked well Worked well, no complaints.

Date published: 2015-07-16

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