Pitavastatin CalciumA competitive inhibitor of HMG-CoA reductase

Pitavastatin Calcium (CAS 147526-32-7)

Pitavastatin Calcium | CAS 147526-32-7 is rated 5.0 out of 5 by 2.
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Synonym: Pitavastatin hemicalcium; Nisvastatin
Application: A competitive inhibitor of HMG-CoA reductase
CAS Number: 147526-32-7
Purity: ≥98%
Molecular Weight: 880.98
Molecular Formula: C50H46CaF2N2O8
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pitavastatin Calcium is a competitive inhibitor of the enzyme HMGCR (HMG-CoA reductase) results in a reduction in LDL cholesterol synthesis. Alternate studies show that pitavastatin can suppress oxygen production in endothelial cells by inhibiting Nox (NADPH oxidase). In addition, pitavastatin reduces the expression of eNOS mRNA while increasing the NO dependent response stimulated by acetylcholine and the calcium ionophore, A23187 (sc-3591). Furthermore, pitavastatin inhibits the up-regulation of conductance calcium-activated potassium channels by lowering cholesterol levels in cells.


References

1. Kajinami, K., et al. 2003. Cardiovasc Drug Rev. 21: 199-215. PMID: 12931254
2. Terata, Y., et al. 2003. Pharmacology. 68: 169-176. PMID: 12837970
3. Hayashi, T., et al. 2004. Atherosclerosis. 176: 255-263. PMID: 15380447
4. Takayama, T., et al. 2004. Circ. J. 68: 1067-1075. PMID: 15502390

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mMl), water (<1 mg/ml), and ethanol (<1 mg/ml).
Storage :
Store at room temperature
Boiling Point :
692° C at 760 mmHg
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5282451
SMILES :
O[C@H](/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1)C[C@@H](O)CC(=O)O[Ca]OC(=O)C[C@H](O)C[C@H](O)/C=C/c1c(nc2ccccc2c1c1ccc(F)cc1)C1CC1

Download SDS (MSDS)

Certificate of Analysis

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Pitavastatin Calcium  Product Citations

See how others have used Pitavastatin Calcium. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 25993292  Yoshimura, K. et al. 2015. Int J Mol Sci. 16: 11213-28.

PMID: # 24671957  Chang, JH. et al. 2014. Drug Metab. Dispos. 42: 1067-73.

PMID: # 23750830  Chang, JH. et al. 2013. Mol. Pharm. 10: 3067-75.

PMID: # 23564645  Zhang, X. et al. 2013. Toxicological sciences : an official journal of the Society of Toxicology. 134: 73-82.

Citations 1 to 4 of 4 total

Could I ask how long could the Pitavastatin calcium powder keep stable in room temperature, Last time we bought a lot, and keep some of the power in -20 degree for several years, do you think it still works well? and how to store DMSO solution, thanks

Asked by: zhihua
Thank you for your question. It is okay to store sc-208176 at -20&ordm;C. Storing at -20&ordm;C may prolong the shelf life. It is recommended to retest the chemical before use after 1 year. It is also recommended to use solutions the same day they are made. If solutions need to be stored, we recommend to aliquot and freeze it. If stored in this way, solutions should be used within one month and multiple freeze/thaw cycles should be avoided.
Answered by: Technical Support
Date published: 2019-03-15

dear SIr/ Madam, I want to by pitavastatin ( original form not salt form), so do your company sell it? i am loooking forward to your reply soon. Thank you very much

Asked by: MAI THI PHUONG
Thank you for your question. Unfortunately, we do not offer non-salt form of Pitavastatin.
Answered by: Technical Support
Date published: 2017-11-09

I bought pitavastatin. But I did not have solubility in the datasheet. Can I dissolve in DMSO? Can I make the stock concentration 50 ~ 100mM?

Asked by: spring
Thank you for your question. Pitavastatin Calcium (CAS 147526-32-7) is soluble in DMSO at 51 mg/mL (57.89 mM).
Answered by: Technical Support
Date published: 2017-02-04

Is it possible to store this compound in -18&deg;C when it is diluted into methanol?

Asked by: two2igm05
Thank you for your question. We recommend storing it as -80 degrees Celsius after re-suspension, and using it within 6 months. Please contact Technical Service if you have further questions concerning this product.
Answered by: Tech Service 9
Date published: 2016-12-19
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Rated 5 out of 5 by from The chemical works well in our animal studies The chemical works well in our animal studies, will order again.
Date published: 2015-10-12
Rated 5 out of 5 by from Shibasaki Shibasaki, M. et al. (PubMed 26367531) found that Pitavastatin (Pitavastatin hemicalcium; Nisvastatin), a competitive inhibitor of HMG-CoA reductase, reduced inflammation in atherosclerotic plaques in apolipoprotein E-deficient mice with late stage renal disease. -SCBT Publication Review
Date published: 2015-03-04
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