PiroxicamAn inhibitor of prostaglandin synthesis as well as Cox-1 and Cox-2

Piroxicam (CAS 36322-90-4)

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Synonym: Feldene
Application: An inhibitor of prostaglandin synthesis as well as Cox-1 and Cox-2
CAS Number: 36322-90-4
Molecular Weight: 331.35
Molecular Formula: C15H13N3O4S
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Piroxicam is an effective and potent inhibitor of prostaglandin synthesis and a Cox-1 and Cox-2 inhibitor. Studies show that Piroxicam blocks release of platelet ADP, and inhibits Cox-1 (human prostaglandin H synthase isozyme-1, hPGHS-1) more potently than Cox-2 (hPGHS-2). Piroxicam is also a non-steroidal compound with anti-inflammatory properties.


References

1. Gaynor, B.J. and Constantine, J.W. 1979. Experientia. 35: 797-798. PMID: 467595
2. Carty, T.J., et al. 1980. Prostaglandins. 19: 51-59. PMID: 7384538
3. Laneuville, O., et al. 1994. J. Pharmacol. Exp. Ther. 271: 927-934. PMID: 7965814

Physical State :
Solid
Solubility :
Soluble in water (Partly miscible), DMSO (25 mg/mL warm), ethanol (5 mg/mL warm), chloroform, ethyl acetate, DMF (~20 mg/mL), and 1:1 solution of DMSO:PBS(pH 7.2) (~0.5 mg/mL).
Storage :
Store at -20° C
Refractive Index :
n20D 1.69
IC50 :
COX-1: IC50 = 1.57 µM; COX-2: IC50 = 1.69 µM; PGHS-1: IC50 = 17.7 µM; PGHS-2: IC50 = >500 µM; PGE2 generation: IC50 = 0.1 µM (stimulated rat synovial cells)
pK Values :
pKa: 4.5, 6.3 in 2:1 dioxane:water, pKb: 3.56
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DL0705000
PubChem CID :
54676228
Merck Index :
14: 7506
MDL Number :
MFCD00057317
EC Number :
252-974-3
Beilstein Registry :
627692
SMILES :
CN1C(=C(C2=CC=CC=C2S1(=O)=O)O)C(=O)NC3=CC=CC=N3

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Certificate of Analysis

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Piroxicam  Product Citations

See how others have used Piroxicam. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 23933501  Hsu, YH. et al. 2013. Mol. Cell. Endocrinol. 381: 168-74.

Citations 1 to 1 of 1 total
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