Piriprost (potassium salt)CAS: 88851-62-1
MF: C26H34NO4K
MW: 463.65
A structural analog of prostaglandin I2.

Piriprost (potassium salt) (CAS 88851-62-1)

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Synonym: U-60257B
Application: A structural analog of prostaglandin I2
CAS Number: 88851-62-1
Purity: >98%
Molecular Weight: 463.65
Molecular Formula: C26H34NO4K
* Refer to Certificate of Analysis for lot specific data (including water content).
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Piriprost (potassium salt) is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. It inhibits 5-LO (5-lipoxygenase; IC50 ~ 100 μM, as measured by the release of 5-HETE from cultured myometrial cells). Also inhibits the release of histamine and leukotrienes from isolated porcine lung cells (IC50 = 0.11 μM), implicating its role in allergic responses and inflammation.


References

1 Cejic, S.S., Kennedy, T.G. Examination of the effects of piriprost (U-60, 257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins 42 179-189 (1991). 2 McCormack, D.G., Peterson, N.A.M. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis 139 100-105 (1989).

Physical State :
Solid
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
23665631
MDL Number :
MFCD02259346
SMILES :
CCCCC[[email protected]@H](/C=C/[[email protected]]1[[email protected]@H](CC2=C1C=C(N2C3=CC=CC=C3)CCCCC(=O)[O-])O)O.[K+]

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Certificate of Analysis

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