Piriprost (potassium salt) is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. It inhibits 5-LO (5-lipoxygenase; IC50 ~ 100 μM, as measured by the release of 5-HETE from cultured myometrial cells). Also inhibits the release of histamine and leukotrienes from isolated porcine lung cells (IC50 = 0.11 μM), implicating its role in allergic responses and inflammation.
1 Cejic, S.S., Kennedy, T.G. Examination of the effects of piriprost (U-60, 257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins 42 179-189 (1991). 2 McCormack, D.G., Peterson, N.A.M. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis 139 100-105 (1989).
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