Molecular structure of Piriprost (potassium salt), CAS Number: 88851-62-1
Piriprost (potassium salt) (CAS 88851-62-1)
Alternate Names:
U-60257B
Application:
Piriprost (potassium salt) is a structural analog of prostaglandin I2
CAS Number:
88851-62-1
Purity:
>98%
Molecular Weight:
463.65
Molecular Formula:
C26H34NO4K
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
A structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. It inhibits 5-lipoxygenase with an IC50 around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.1 Also inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 of 0.11 µM, implicating its role in allergic responses and inflammation.2
Piriprost (potassium salt) (CAS 88851-62-1) References
- Effects of piriprost (U-60, 257B) and leukotrienes on alkaline phosphatase activity of rat endometrial stromal cells in vitro. | Cejic, SS. and Kennedy, TG. 1991. Prostaglandins. 42: 163-79. PMID: 1663640
- Examination of the effects of piriprost (U-60,257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. | Cejic, SS. and Kennedy, TG. 1991. Prostaglandins. 42: 179-89. PMID: 1775638
- The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. | McCormack, DG. and Paterson, NA. 1989. Am Rev Respir Dis. 139: 100-5. PMID: 2463778
- Pulmonary response to free fatty acid intravenous infusion in the rabbit: role of leukotrienes and the effect of prostacyclin. | Arenas, G., et al. 1989. Arch Biol Med Exp. 22: 379-85. PMID: 2488536
- Inhibition of the leukotriene synthetase of rat basophil leukemia cells by diethylcarbamazine, and synergism between diethylcarbamazine and piriprost, a 5-lipoxygenase inhibitor. | Bach, MK. and Brashler, JR. 1986. Biochem Pharmacol. 35: 425-33. PMID: 3004501
- Enhancement of endotoxin-induced isolated renal tubular cell injury by toxic shock syndrome toxin 1. | Keane, WF., et al. 1986. Am J Pathol. 122: 169-76. PMID: 3079956
- Effect of Piriprost, a 5-lipoxygenase inhibitor, on leukocyte accumulation during thioglycollate-induced acute inflammation. | Lawson, CF., et al. 1986. Wien Klin Wochenschr. 98: 110-3. PMID: 3085355
- Experiments on the mode of action of piriprost (U-60,257), an inhibitor of leukotriene formation in cloned mouse mast cells and in rat basophil leukemia cells. | Bach, MK., et al. 1987. Biochem Pharmacol. 36: 1461-6. PMID: 3107573
- Inhibition of human platelet and neutrophil function by piriprost (U-60,257). | Mehta, JL., et al. 1987. Prostaglandins Leukot Med. 29: 259-67. PMID: 3124134
- Inhibition of the 5-lipoxygenase pathway with piriprost (U-60,257) protects normal primates from ozone-induced methacholine hyperresponsive small airways. | Johnson, HG., et al. 1988. Prostaglandins. 35: 459-66. PMID: 3287458
- Ethacrynic acid and piriprost as enhancers of cytotoxicity in drug resistant and sensitive cell lines. | Tew, KD., et al. 1988. Cancer Res. 48: 3622-5. PMID: 3288331
- Piriprost: a putative leukotriene synthesis inhibitor increases pulmonary blood flow in fetal lambs. | Lebidois, J., et al. 1987. Pediatr Res. 22: 350-4. PMID: 3309861
- Effect of inhaled piriprost (U-60, 257) a novel leukotriene inhibitor, on allergen and exercise induced bronchoconstriction in asthma. | Mann, JS., et al. 1986. Thorax. 41: 746-52. PMID: 3538476
- Inhibition of rat liver glutathione S-transferases by piriprost: kinetics of the inhibition and preliminary evidence that piriprost may be a poor alternative substrate for these enzymes. | Bach, MK., et al. 1985. Res Commun Chem Pathol Pharmacol. 49: 361-86. PMID: 3903894
- Inhibition of the presumably leukotriene-dependent component of antigen-induced bronchoconstriction in the guinea pig by piriprost (U-60,257). | Bach, MK., et al. 1985. Int Arch Allergy Appl Immunol. 77: 264-6. PMID: 3924840
Inhibitor of:
5-LO, and Enzyme.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Piriprost (potassium salt), 1 mg | sc-205440 | 1 mg | $82.00 | |||
Piriprost (potassium salt), 5 mg | sc-205440A | 5 mg | $370.00 |