PiperineA black pepper extract TRPV1 activator

Piperine (CAS 94-62-2)

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Synonym: 1-Piperoylpiperidine
Application: A black pepper extract TRPV1 activator
CAS Number: 94-62-2
Purity: ≥95%
Molecular Weight: 285.34
Molecular Formula: C17H19NO3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Piperine is an alkaloid from black pepper that shows chemopreventive, cytotoxic, anti-inflammatory, and antioxidant effects. It is suggested that piperine exerts its chemopreventive effect by augmenting antioxidant defense system and modulating lipid peroxidation.


References

Sunila ES, Kuttan G. J Ethnopharmacol. 90:339-46 (2004). Selvendiran K, Senthilnathan P, Magesh V et al. Phytomedicine. 11:85-9 (2004). Mittal R, Gupta RL. Methods Find Exp Clin Pharmacol. 22:271-4 (2000).

Physical State :
Solid
Solubility :
Soluble in ethanol (57 mg/ml), DMSO (57 mg/ml), alcohol (66.67 mg/ml), chloroform (588.24 mg/ml), and ether (27.78 mg/ml).
Storage :
Store at room temperature
Melting Point :
128-133° C
Boiling Point :
~458.5° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
Trypanosoma cruzi: IC50 = 4.91 nM; Monoamine oxidase B: IC50 = 260 nM (rat); Monoamine oxidase A: IC50 = 404 nM (rat); D-galactosamine/TNFalpha-induced cytotoxicity: IC50 = 12 µM; Mdr-1: IC50 = 15.5 µM (human)
Ki Data :
Monoamine oxidase B: Ki= 3.19 µM (mouse); Monoamine oxidase A: Ki= 19 µM (mouse); Monoamine oxidase A: Ki= 49.3 µM (rat); Monoamine oxidase B: Ki= 91.3 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TN2321500
PubChem CID :
638024
Merck Index :
14: 7472
MDL Number :
MFCD00005839
EC Number :
202-348-0
Beilstein Registry :
90741
SMILES :
C1CCN(CC1)C(=O)/C=C/C=C/C2=CC3=C(C=C2)OCO3

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Certificate of Analysis

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Piperine  Product Citations

See how others have used Piperine. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28739698  Park, Y.|Son, JY.|Lee, BM.|Kim, HS.|Yoon, S.| et al. 2017. Anticancer Res. 37: 4139-4146.

Citations 1 to 1 of 1 total
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