PindololCAS: 13523-86-9
MF: C14H20N2O2
MW: 248.32
A SR-1A/SR-1B antagonist.

Pindolol (CAS 13523-86-9)

Pindolol | CAS 13523-86-9 is rated 5.0 out of 5 by 1.
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Synonym: 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
Application: A SR-1A/SR-1B antagonist
CAS Number: 13523-86-9
Purity: ≥90%
Molecular Weight: 248.32
Molecular Formula: C14H20N2O2
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pindolol is a SR-1A/SR-1B antagonist with similar affinity for each subtype. Pindolol acts as a partial agonist at mouse and human β3-AR (β3-adrenoceptors). Pindolol is an inhibitor of β1-AR.


References

1. Blin, N., et al. 1993. Mol. Pharmacol. 44: 1094-1104. PMID: 7903415
2. Hoyer, D., et al. 1994. Pharmacol. Rev. 46: 157-203. PMID: 7938165
3. Clifford, E.M., et al. 1998. Br. J. Pharmacol. 124: 206-212. PMID: 9630361

Physical State :
Solid
Solubility :
Soluble in 0.1 M NaOH (0.2 mg/ml), DMSO (100 mM), methanol, and ethanol (with heating, 25 mM). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
167-171° C (lit.)
Boiling Point :
~457.1° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
β2-AR : IC50 = 0.55 nM (human); β1-AR: IC50 = 0.92 nM (human); SR-1B: IC50 = 6.8 nM; SR-1A: IC50 = 48 nM (rat); beta3-AR : IC50 = 88 nM (human)
Ki Data :
β2-AR : Ki= 0.38 nM (human); β1-AR: Ki= 0.52 nM (human); SR-1A: Ki= 8.9 nM; SR-1B: Ki= >10 µM (human); SR-2C: Ki= 54 µM (human)
pK Values :
pKa: 13.94 (Predicted), pKb: 9.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UB6660000
PubChem CID :
4828
Merck Index :
14: 07443
MDL Number :
MFCD00010530
EC Number :
236-867-9
Beilstein Registry :
1536506
SMILES :
CC(C)NCC(O)COC1=CC=CC2=C1C=CN2

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Certificate of Analysis

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Rated 5 out of 5 by from Clifford et al Clifford et al. (PubMed ID 9630361) found that pindolol showed agonist effects at the 5-HT1A autoreceptor. -SCBT Publication Review
Date published: 2015-01-22
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