Pimozide CAS: 2062-78-4
MF: C28H29F2N3O
MW: 461.55
A D2DR, SR-7, and calcium channel protein inhbitor.

Pimozide (CAS 2062-78-4)

Pimozide | CAS 2062-78-4 is rated 5.0 out of 5 by 1.
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Alternate Names: Orap; Opiran; Neoperidole; Pimozidum
Application: Pimozide is a D2DR, SR-7, and calcium channel protein inhbitor
CAS Number: 2062-78-4
Molecular Weight: 461.55
Molecular Formula: C28H29F2N3O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pimozide is a D2DR inhibitor and antipsychotic which binds with very high affinity and inhibits SR-7 (Ki = 0.5 nM). Pimozide blocks establishment but not expression of amphetamine produced environment specific conditioning. Pimozide is a calcium channel protein inhibitor.


References

1. Roth, B.L., et al. 1994. J. Pharmacol. Exp. Ther. 268: 1403-1410. PMID: 7908055

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM), and chloroform (25 mg + 5 mL of CHCl3). Insoluble in water.
Storage :
Store at room temperature
Melting Point :
214-218° C
Boiling Point :
584.61° C (Predicted)
Density :
1.23 g/cm3 (Predicted)
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
Dopamine receptor: IC50 = 0.4 nM (rat); HERG: IC50 = 3.02 nM (human); Sodium channel protein type II alpha subunit: IC50 = 340 nM (rat); MOR-1: IC50 = 372 nM (human); Mdr-1: IC50 = 800 nM (human)
Ki Data :
5-HT7 receptor: Ki= 0.5 nM (rat); Dopamine D2 receptor: Ki= 0.6 nM (bovine); D2DR: Ki= 11.7 nM (human); HERG: Ki= 42 nM (human); SR-6: Ki= 71 nM (human)
pK Values :
pKa: 12.05 (Predicted), pKb: 9.26 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DE1750000
PubChem CID :
Merck Index :
14: 7435
MDL Number :
MFCD00055081
EC Number :
218-171-7
Beilstein Registry :
729089
SMILES :
C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCCC(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F

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Certificate of Analysis

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Pimozide (CAS 2062-78-4)  Product Citations

See how others have used Pimozide (CAS 2062-78-4). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 33119612  PLoS One. e0232438.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Gosiewski G; et al Gosiewski G; et al. (PubMed ID: 26103682) utilized Pimozide to evoke LH scretion in studying KISS1 activity in gonad recrudescence. -SCBT Publication Review
Date published: 2015-05-19
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