Pimelic Diphenylamide 106An HDAC1, HDAC2, HDAC3, and HDAC8 inhibitor

Pimelic Diphenylamide 106 (CAS 937039-45-7)

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Synonym: TC-H 106; Histone Deacetylase Inhibitor VII
Application: An HDAC1, HDAC2, HDAC3, and HDAC8 inhibitor
CAS Number: 937039-45-7
Molecular Weight: 339.43
Molecular Formula: C20H25N3O2
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDACs (histone deacetylases). With prolonged preincubation (1-3 hours), pimelic diphenylamide inhibits the class I HDAC1, HDAC2, HDAC3, and HDAC8 (IC50 = 150, 760, 370, and 5,000 nM, respectively) but not the class II HDAC4, HDAC5, and HDAC7 (IC50 > 180 μM).


References

PMID: 18953021 PMID: 18463734 PMID: 16921367 PMID: 18829438

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in ethanol (~0.3 mg/ml), DMSO (~20 mg/ml), DMF (~20 mg/ml), and 1: 1 DMSO: PBS (pH 7.2) (~0.5 mg/ml).
Storage :
Store at -20° C
Melting Point :
258.62° C
Boiling Point :
~627.3° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
16070100
MDL Number :
MFCD17010287
SMILES :
CC1=CC=C(C=C1)NC(=O)CCCCCC(=O)NC2=CC=CC=C2N

Download SDS (MSDS)

Certificate of Analysis

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