Pimaricin, Streptomyces chattanoogensis is an antifungal macrolide polyene that binds to cell membrane sterols. Investigations show that the compound predominantly binds to the main sterol in fungal and yeast membranes, ergosterol. Ergosterol is a building block of yeasts and molds, which is responsible for intracellular nutrient transport, and therefore vital for their survival. As ergosterol is not present in the outer membranes of bacteria, these remain unaffected.
Pimarcin has been used as a fungicide in agar media and CYP (cytochrome P450) PimD research proposes that the epoxidiation of Pimaricin occurs through a hydroperoxoferric compound. Pimarcin studies reveal that the regulator PimM binds to eight promoters of Pimarcin genes and its biosynthesis is influenced by a cholesterol oxidase protein encoded by PimE.
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