PIK-90 CAS: 677338-12-4
MF: C18H17N5O3
MW: 351.36
A selective inhibitor of PI3K isoforms.

PIK-90 (CAS 677338-12-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 106ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Alternate Names: PI 3-K inhibitor IX
Application: PIK-90 is a selective inhibitor of PI3K isoforms
CAS Number: 677338-12-4
Purity: ≥99%
Molecular Weight: 351.36
Molecular Formula: C18H17N5O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
loading

PIK-90 selectively inhibits different subsets of four class I PI3K isoforms (IC50 = 11, 350, 58, and 18 nM for PI3Kα, -β, -δ, and γ, respectively). In addition, PIK-90 completely inhibits the fMLP-stimulated phosphorylation of Akt and impairs polarity and chemotaxis in dHL60 cells, resulting in antiproliferative activity in certain glioma cell lines including U87 MG, SF188, SF763, LN229, A1207 and LN-Z30 cells. In chronic lymphocytic leukemia (CLL) cells, PIK-90 inhibits chemotaxis to levels that are 57.8% of controls at 1 μM and 56.8% of controls at 10 μM.

Physical State :
Solid
Storage :
Store at -20° C
Melting Point :
229.73° C (Predicted)
Boiling Point :
536.66° C (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
SMILES :
COC1=C(C2=C(C=C1)C3=NCCN3C(=N2)NC(=O)C4=CN=CC=C4)OC

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 92ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 7ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;