PIK-75, free baseCAS: 372196-67-3
MF: C16H14BrN5O4S
MW: 452.28
A free base is a selective inhibitor of PI 3-kinase p110α.

PIK-75, free base (CAS 372196-67-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 145ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Synonym: 2-Methyl-5-nitrobenzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide
Application: A free base is a selective inhibitor of PI 3-kinase p110α
CAS Number: 372196-67-3
Purity: ≥98%
Molecular Weight: 452.28
Molecular Formula: C16H14BrN5O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

PIK-75, free base is a selective inhibitor of PI 3-kinase p110α (IC50 values are 5.8, 76 nM and 1.3 μM at PI 3-kinase p110α, PI 3-kinase p110γ and PI 3-kinase p110β respectively). Inhibits production of PIP2 and PIP3 in adipocytes, phosphorylation of Akt and activation of mTORC1. Cell-permeable.

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in DMSO (5 mM).
Storage :
Desiccate at -20° C
IC50 :
p110α: IC50 = 5.8 nM; p110γ: IC50 = 76 nM; p110β: IC50 = 1.3 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
9825070
SMILES :
CC1=C(C=C(C=C1)[N+](=O)[O-])S(=O)(=O)N(C)/N=C\\C2=CN=C3N2C=C(C=C3)Br

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

PIK-75, free base  Product Citations

See how others have used PIK-75, free base. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 30606984  Hamada, K.|Maeda, Y.|Mizutani, A.|Okada, S.| et al. 2019. Biol. Pharm. Bull. 42: 130-138.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 129ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 15ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.