PicrotoxinA GABAA receptor antagonist

Picrotoxin (CAS 124-87-8)

Picrotoxin | CAS 124-87-8 is rated 5.0 out of 5 by 2.
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Synonym: Cocculin
Application: A GABAA receptor antagonist
CAS Number: 124-87-8
Molecular Weight: 602.58
Molecular Formula: C15H18O7•C15H16O6
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Picrotoxin is a GABAA receptor antagonist. This compound has been shown to increase noradrenaline levels and turnover in the hypothalamus. Administration of Picrotoxin into the supramammillary nucleus has been noted to increase c-Fos expression in the region, which disinhibits local neurons. Additional studies suggest that Picrotoxin significantly increases [35S]TBPS and [3H]muscimol (sc-200460) binding in the cerebellum, but causes no change in the frontal cortex.


References

1. Akaike, N., et al. 1985. Experientia. 41: 70-71. PMID: 2578409
2. Ito, Y., et al. 1989. J. Neurochem. 52: 1064-1070. PMID: 2538560
3. Yoon, K.W., et al. 1993. J. Physiol. 464: 423-439. PMID: 8229811
4. Qian, H. and Dowling, J.E. 1994. J. Neurosci. 14: 4299-4307. PMID: 8027780
5. Stankevicius, D., et al. 2008. Neuropharmacology. 54: 300-308. PMID: 18022650
6. Shin, R. and Ikemoto, S. 2010. BMC Neurosci. 11: 101. PMID: 20716371

Physical State :
Solid
Solubility :
Soluble in ethanol (50 mg/ml,Clear to Slightly Hazy), DMSO (100 mM), methanol (Easily), water (200 mg/ml at 100° C), and basic aqueous solutions (3 mg/ml).
Storage :
Store at room temperature
Melting Point :
203° C (lit.)
Boiling Point :
595.8° C at 760 mmHg
Optical Activity :
α20/D -34.5°±5.5°, c = 4 in ethanol
IC50 :
GABA receptors : IC50 = 0.24 µM; 35S-TBPS binding to the Cl– channel: IC50 = 1.7 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
TJ9100000
PubChem CID :
31304
Merck Index :
14: 7415
MDL Number :
MFCD00074824
EC Number :
204-716-6
Beilstein Registry :
3894406
SMILES :
CC(=C)C1C2C3C4(C(C1C(=O)O2)(CC5C4(O5)C(=O)O3)O)C.CC12C3C4C(C(C1(CC5C2(O5)C(=O)O3)O)C(=O)O4)C(C)(C)O

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Picrotoxin  Product Citations

See how others have used Picrotoxin. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 29771335  Lee, K.Y. et al. 2018. Human molecular genetics.

PMID: # 27000207  Jewett, KA. et al. 2016. Mol Brain. 9: 32.

PMID: # 27624155  Pougnet, JT. et al. 2016. Sci Rep. 6: 31836.

PMID: # 26250624  Jewett, K. et al. 2015. J Neurochem.

Citations 1 to 4 of 4 total
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Rated 5 out of 5 by from Consistent quality We have been used this chemical for 4 years and are very satisfied with its quality.
Date published: 2018-06-05
Rated 5 out of 5 by from Published paper in which we used it to elevate Published paper in which we used it to elevate neuronal activity by treating primary mouse cortical neuron cultures.
Date published: 2015-08-12
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