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Piceatannol is a catechol-type polyphenol. The compound has been shown to act as a protein-tyrosine kinase inhibitor, and preferentially inhibits Syk in comparison to Lyn in in vitro kinase assays. In MCF-10A cell studies, Piceatannol inhibited phorbol ester-induced NF-κB activation and cyclooxygenase-2 expression. Research indicates that Piceatannol can upregulate Fas and FasL through AFT2 and Ca2+/p38α MAPK-mediated activation of c-Jun pathways. Identified as a potential inhibitor of PKA, PKC, MYLK, Lck, and IKKβ as well as an activator of SIRT1. SIRT1 is an NAD+ dependent deacetylase that is known to target histone H4. Piceatannol is an inhibitor of CaMK, JNK, IKKα and PI 3-kinase. Piceatannol is an activator of caspase-3.
1. Oliver, J.M., et al. 1994. J. Biol. Chem. 269: 29697-29703. PMID: 7961959
2. Son, P.S., et al. 2010. Carcinogenesis. 31: 1442-1449. PMID: 20584749
3. Liu, W.H., et al. 2010. Int. J. Biochem. Cell Biol. 42: 1498-1506. PMID: 20580678
See how others have used Piceatannol. Click on the entry to view the PubMed entry .
PMID: # 28684421 Perez-Leal, O. et al. 2017. J. Biol. Chem.
PMID: # 28248427 Paasela, T. et al. 2017. New Phytol. 214: 1537-1550.
PMID: # 28603085 Fernández-Del-Río, L. et al. 2017. Free Radic. Biol. Med. 110: 176-187.
PMID: # 27129263 Wu, Y. et al. 2016. J. Biol. Chem. 291: 12370-82.
PMID: # 27619995 Wu, Y. et al. 2016. J. Immunol.
PMID: # 7961959 Oliver, J.M. et al. 1994. J. Biol. Chem. 269: 29697-29703.
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