Anti-PI 3-kinase p110δ Antibody (A-8) is a mouse monoclonal IgG1 κ PI 3-kinase p110δ antibody, cited in 19 publications, provided at 200 µg/ml
raised against amino acids 363-582 mapping at the N-terminus of PI 3-kinase p110δ of human origin
Anti-PI 3-kinase p110 delta Antibody (A-8) is recommended for detection of PI 3-kinase p110δ of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
Anti-PI 3-kinase p110 delta Antibody (A-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PI 3-kinase p110δ (A-8): sc-55589.
m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for PI 3-kinase p110δ Antibody (A-8) for WB and IHC(P) applications. These reagents are now offered in bundles with PI 3-kinase p110δ Antibody (A-8) (see ordering information below).
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PI 3-kinase p110δ Antibody (A-8) is a high quality monoclonal PI 3-kinase p110 delta antibody (also designated PI3K antibody, p110 delta antibody, PIK3CD antibody or phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta antibody) suitable for the detection of the PI 3-kinase p110 delta protein of mouse, rat and human origin. PI 3-kinase p110δ Antibody (A-8) is available as both the non-conjugated anti-PI 3-kinase p110 delta antibody form, as well as multiple conjugated forms of anti-PI 3-kinase p110 delta antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 forms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. It has been shown to bind p85α and β, but it apparently does not phosphorylate these subunits. p110δ has the capacity to autophosphorylate and results in the nearly complete inactivation of the lipid kinase activity. Interestingly, p110γ does not interact with the p85 subunits and has been shown to be activated by α and βγ heterotrimeric G proteins. Two p110δ isoforms have been identified and are widely expressed. Isoform 1 is expressed predominantly in leukocytes while isoform 2 is expressed in normal thymus, lung and spleen tissues.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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