Anti-PI 3-kinase p110 Antibody (D-4) is a mouse monoclonal IgG2a κ PI 3-kinase p110 antibody, cited in 35 publications, provided at 200 µg/ml
raised against amino acids 800-1039 mapping at the C-terminus of PI 3-kinase p110 of human origin
PI 3-kinase p110 Antibody (D-4) is recommended for detection of PI 3-kinase p110 of human origin by WB, IP, IF and ELISA
Anti-PI 3-kinase p110 Antibody (D-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
Contact our Technical Service Department (or your local Distributor) for more information on how to receive a FREE 10 µg sample of PI 3-kinase p110 (D-4): sc-8010.
m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for PI 3-kinase p110 Antibody (D-4) for WB applications. These reagents are now offered in bundles with PI 3-kinase p110 Antibody (D-4) (see ordering information below).
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PI 3-kinase p110 Antibody (D-4) is a high quality monoclonal PI 3-kinase p110 antibody (also designated PI3K antibody, p110 antibody or phosphatidylinositol-4,5-bisphosphate 3-kinase antibody) suitable for the detection of the PI 3-kinase p110 protein of human origin. PI 3-kinase p110 Antibody (D-4) is available as both the non-conjugated anti-PI 3-kinase p110 antibody form, as well as multiple conjugated forms of anti-PI 3-kinase p110 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Phosphatidylinositol 3-kinase (PI 3-kinase) is composed of p85 and p110 subunits. p85 lacks PI 3-kinase activity and acts as an adapter, coupling p110 to activated protein tyrosine kinase. Two forms of p85 have been described (p85α and p85β), each possessing one SH3 and two SH2 domains. Various p110 isoforms have been identified. p110α and p110β interact with p85α, and p110α has also been shown to interact with p85β in vitro. p110δ expression is restricted to white blood cells. It has been shown to bind p85α and β, but it apparently does not phosphorylate these subunits. p110δ seems to have the capacity to autophosphorylate. p110γ does not interact with the p85 subunits. It has been shown to be activated by α and βγ heterotrimeric G proteins.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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