Phytosphingosine CAS: 554-62-1
MF: C18H39NO3
MW: 317.51
A sphingolipid signaling molecule.

Phytosphingosine (CAS 554-62-1)

Phytosphingosine | CAS 554-62-1 is rated 5.0 out of 5 by 1.
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Alternate Names: 4-D-Hydroxysphinganine
Application: Phytosphingosine is a sphingolipid signaling molecule
CAS Number: 554-62-1
Purity: 98%
Molecular Weight: 317.51
Molecular Formula: C18H39NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Phytosphingosine is a sphingolipid endogenous to many organisms involved in cell signaling. Apoptosis is signaled by the presence of Phytosphingosine, with the induction of apoptosis accompanied by activation of caspase-8-mediated and mitochondrial activation-mediated apoptotic pathways. An increase in p38 MAPK phosphorylation is noted upon Phytosphingosine introduction, and a study describes two distinctly different p38 MAPK-mediated apoptotic pathways initiated by Phytosphingosine. The eukaryotic heat shock response also involves signaling with Phytosphingosine for activation of a ubiquitin protein degradation pathway.


References

1. Wu, W.I., et al. 1995. J. Biol. Chem. 270: 13171-13178. PMID: 7768913
2. Jenkins, G.M., 2003. Cell. Mol. Life Sci. 60: 701-710. PMID: 12785717
3. Park, M.T., et al. 2003. J. Biol. Chem. 278: 50624-50634. PMID: 14522966
4. Nagahara, Y., et al. 2005. Cancer Sci. 96: 83-92. PMID: 15723652

Physical State :
Solid
Solubility :
Soluble in ethanol (2 mg/ml), DMSO, methanol, and pyridine.
Storage :
Store at -20° C
Melting Point :
102° C (lit.)
Boiling Point :
483.73° C at 760 mmHg (Predicted)
Density :
0.98 g/cm3 (Predicted)
Refractive Index :
n20D 1.49 (Predicted)
Optical Activity :
α20/D +9°, c = 1 in Pyridine
IC50 :
Jurkat (Acute leukemic T-cells): IC50 = 3.75 µM (human)
pK Values :
pKa: 11.91 (Predicted), pKb: 7.98 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
1
PubChem CID :
MDL Number :
MFCD00079232
Beilstein Registry :
1725301
SMILES :

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Phytosphingosine (CAS 554-62-1)  Product Citations

See how others have used Phytosphingosine (CAS 554-62-1). Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 27637314  Fischer, C. et al. 2016. J. Biotechnol. 238: 30-34.

PMID: # 22773104  Li, L. et al. 2012. Nat. Struct. Mol. Biol. 19: 824-30.

PMID: # 16225461  Tani M. et al. 2006. Biochem J. 394: 237-242.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from An increase in cleaved PARP An increase in cleaved PARP-1 was observed by WB for Jurkat cells post treatment with Phytosphingosine. -SCBT QC
Date published: 2015-04-25
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