Phytic acid dipotassium salt is present in all eukaryotic cells. In plants, phytic acid dipotassium salt functions as a [PO4]3- storage depot and precursor for other inositol phosphates and pyrophosphates. Its high surface negative charge makes it a potent chelator of divalent and trivalent cations in vitro. In yeast, phytic acid acts with the nuclear pore protein Gle1 to regulate the nuclear export of mRNA by coactivating the RNA-dependent ATPase activity of DExD-box protein 5 (Dbp5).
Shears, S.B., Assessing the omnipotence of inositol hexakisphosphate. Cell. Signal. 13, 151-158, (2001) Raboy, V., myo-Inositol-1,2,3,4,5,6-hexakisphosphate. Phytochemistry 64, 1033-1043, (2003) Weirich, C.S., et al., Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export. Nat. Cell Biol. 8, 668-676, (2006) Alcazar-Roman, A.R., et al., Inositol hexakisphosphate and Gle1 activate the DEAD-box protein Dbp5 for nuclear mRNA export. Nat. Cell Biol. 8, 711-716, (2006)
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