PHT-427 is a a pleckstrin homology domain inhibitor with dual Akt and PKB Kinase (PDPK1) inhibitory activity(Ki values: Akt = 2.7 μM and PKB Kinase (PDPK1) = 5.2 μM). PHT-427 significantly reduces phosphorylation of phospho-Ser241-PKB Kinase (PDPK1) and phospho-Thr308-Akt in PC-3 prostate cancer cells which shows that PHT-427 could inhibit both Akt and PKB Kinase (PDPK1). PHT-427 also inhibits translocation of the Akt and PKB Kinase (PDPK1) PH domains in plasma membrane. PHT-427 induces apoptosis and inhibits Akt phosphorylation (IC50 = 6.3 μM), mainly on Akt Ser473 residue and less strongly on the Akt Thr308 residue without affecting total Akt protein expression. PHT-427 also shows antiproliferation in Panc-1 cells (IC50 = 65 μM).
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.