Phosphatidic Acid, DioleoylAn activator of multiple PKC isotypes

Phosphatidic Acid, Dioleoyl (CAS 108392-02-5)

Phosphatidic Acid, Dioleoyl | CAS 108392-02-5 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_19, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3-b1
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201059, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 68ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: 1,2-Dioleoyl-sn-glycero-3-phosphate . Na
Application: An activator of multiple PKC isotypes
CAS Number: 108392-02-5
Purity: ≥98%
Molecular Weight: 724
Molecular Formula: C39H73O8PNa
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Phosphatidic Acid, Dioleoyl has been shown to activate PKC α, ε, or ζ isotypes in the cytosol of COS cells. This compound not only stimulates PKC-ζ-mediated phosphorylation of distinctive substrates, but additionally causes an upward shift in electrophoretic mobility of PKC &zeta. Furthermore, experiments have reported Phosphatidic Acid to be generated by hydrolysis of phosphatidylcholine, via phospholipase D (PLD). Mechanistic studies suggest activation of PLD by insulin and consequential generation of Phosphatidic Acid which then induces Raf-1 translocation to cell membranes. Raf-1 is an essential component to the mitogen-activated protein kinase cascade, and once it has crossed over to the plasma membrane, other factors may activate it through phosphorylation.


References

1. Limatola, C., et al. 1994. Biochem. J. 304: 1001-1008. PMID: 7818462
2. Boarder, M.R. 1994. Trends Pharmacol. Sci. 15: 57-62. PMID: 8165726
3. Rizzo, M.A., et al. 1999. J. Biol. Chem. 274: 1131-1139. PMID: 9873061
4. Rizzo, M.A., et al. 2000. J. Biol. Chem. 275: 23911-23918. PMID: 10801816

Physical State :
Solid
Solubility :
Soluble in chloroform (20 mg/ml).
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
71433692
MDL Number :
MFCD00674303
SMILES :
CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)O)OC(=O)CCCCCCCC=CCCCCCCCC.[Na]

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Phosphatidic Acid, Dioleoyl  Product Citations

See how others have used Phosphatidic Acid, Dioleoyl. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26635352  2016. Biochem. J. 473: 509-23.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 56ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Vodicka Vodicka, P. et al. (PubMed 26397899) found changes in Huntington's disease mouse brains via mass spectrometry analysis of wild-type and knock-in Q140/Q140. Significant changes in glycerophospholipids including alterations in Phosphatidic Acid were found in striatum, cerebellum and cortex from Q140/Q140 HD mice compared to WT mice. -SCBT Publication Review
Date published: 2015-06-07
  • y_2019, m_11, d_19, h_13
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.3-b1
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_201059, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 62ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.