Phloxine B is a fluorescein dye which is known to inhibit the enzyme UDP-glucuronosyltransferase (UGT), the main catalyst for the glucuronidation of 7-HC. Additionally, Phloxine B is reported to be a poly(ADP-ribose) glycohydrolase (PARG) inhibitor. As a photoactive dye, Phloxine B is reported to have efficacy against gram-positive organisms. Phloxine B has also been utilized in a study investigating the visible light-induced photodegradation kinetics when coated onto silica TLC plates and in solution. The rapid photodegradation of Phloxine B via visible light exposure was noted and the phototoxicity of the remaining residues were also reported to be decreased.
1. Slabbert, J.C., et al. 1990. J Esthet Dent. 2: 177-180. PMID: 2088435 2. Wang, H., et al. 2008. Biomed. Environ. Sci. 21: 438-441. PMID: 19133619 3. Brovko, L.Y., et al. 2009. J. Food Prot. 72: 1020-1024. PMID: 19517729 4. van Midwoud, P.M., et al. 2010. Anal. Chem. [Epub ahead of print]. PMID: 21128611
Soluble in water (1 mg/ml) (clear red solution).
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Van Midwoud et alVan Midwoud et al. (PubMed ID 21128611) showed that Phloxine B showed a concentration-dependent inhibition of 7-HC glucuronide formation and allowed the calculation of an IC50 value using one single liver slice. -SCBT Publication Review
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