Philanthotoxin 74CAS: 401601-12-5
MF: C24H42N4O3•2HCl
MW: 507.54
An AMPA receptor antagonist.

Philanthotoxin 74 (CAS 401601-12-5)

Philanthotoxin 74 | CAS 401601-12-5 is rated 5.0 out of 5 by 1.
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Synonym: (S)-N-[7-[(4-Aminobutyl)amino]heptyl]-4-hydroxy-α-[(1-oxobutyl)amino]benzenepropanamide dihydrochloride
Application: An AMPA receptor antagonist
CAS Number: 401601-12-5
Purity: ≥98%
Molecular Weight: 507.54
Molecular Formula: C24H42N4O32HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Subtype-selective AMPA receptor antagonist that inhibits GluR1/2 but not GluR2/3 receptors.


References

Nilsen and England (2007) A subtype-selective, use-dependent inhibitor of native AMPA receptors. J.Am.Chem.Soc.129 4902.

Physical State :
Solid
Solubility :
Soluble in water (100 mM), and DMSO (100 mM).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.53 (Predicted)
Optical Activity :
α20/D +1°, c = 2 in water
IC50 :
Glutamate receptor ionotropic, AMPA: IC50 = 138 nM (rat)
Ki Data :
GluR-1: Ki= 168 nM (human); Glutamate receptor ionotropic, AMPA 1: Ki= 168 nM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
46213501
MDL Number :
MFCD09971136
SMILES :
CCCC(=O)N[[email protected]@H](CC1=CC=C(C=C1)O)C(=O)NCCCCCCCNCCCCN.Cl.Cl

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Jackson et al Jackson et al. (PubMed ID 21593335) found that philanthotoxin 74 blocked GluA2-containing AMPARs in cerebellar granule neurons from stargazer mice transfected with transmembrane AMPAR regulatory proteins (TARPs). -SCBT Publication Review
Date published: 2015-05-29
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