Pheophorbide aA chlorophyll-related compound studied for it's anti-tumor & anti-cancer activity

Pheophorbide a (CAS 15664-29-6)

Pheophorbide a | CAS 15664-29-6 is rated 5.0 out of 5 by 1.
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Synonym: 3-[(3S,4S,21R)-14-Ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-9-vinyl-3-phorbinyl]propanoic acid
Application: A chlorophyll-related compound studied for it′s anti-tumor & anti-cancer activity
CAS Number: 15664-29-6
Purity: ≥90%
Molecular Weight: 592.69
Molecular Formula: C35H36N4O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pheophorbide a is a product of chlorophyll breakdown that has been used as a photosensitizer in photodynamic therapy for the treatment of cancer. It has been reported to inhibit U87MG cells with an IC50 value of 2.8 µg/ml and demonstrates cytostatic activity specifically against glioblastoma cells without affecting normal cells. It also displays antiproliferative activity against melanoma, breast, and lung cancer cells in vitro at 100 µg/ml.

Physical State :
Solid
Solubility :
Soluble in DMF, and DMSO.
Storage :
Store at 4° C
Boiling Point :
~1019.0° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
Human immunodeficiency virus 1: IC50 = 2.5 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
5901209
MDL Number :
MFCD00210345
EC Number :
239-738-5
Beilstein Registry :
1208052
SMILES :
CCC1=C2C=C3C(=C4C(=O)C(C(=C5C(C(C(=N5)C=C6C(=C(C(=CC(=C1C)N2)N6)C=C)C)C)CCC(=O)O)C4=N3)C(=O)OC)C

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Certificate of Analysis

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Pheophorbide a  Product Citations

See how others have used Pheophorbide a. Click on the entry to view the PubMed entry .

Citations 1 to 4 of 4 total

PMID: # 31380107  Xu, X. et al. 2018. J Mater Chem B. 6: 7842-7853.

PMID: # 26308358  Hong, CO. et al. 2016. Planta Med. 82: 46-57.

PMID: # 26661076  Ajithkumar, GS. et al. 2016. Cardiovasc. Toxicol. 16: 390-405.

PMID: # 25534417  Jung, KA. et al. 2015. Mol. Pharmacol. 87: 465-76.

Citations 1 to 4 of 4 total

I need 100kg (Pheophorbide), can you supply this amount? what is the CIF price to Cairo, Egypt for such amount ? is your company GMP or ISO certified? And do you comply with the Free sale requirements for this product in the country you operate in?

Asked by: InRaD corporation
Thank you for your question. We can supply this product in smaller quantities only and will not be able to provide this amount. Please contact our European Technical Service team regarding your other questions, they will be able to discuss sale requirements with you. You can reach them by phone at Toll Free: +49 6221 4503 0, by email at: europe@scbt.com or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2016-11-14
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Rated 5 out of 5 by from Hong Hong, CO. et al. (PubMed 26393934) found that Pheophorbide a inhibits advanced glycation end products mediated endothelial dysfunction. -SCBT Publication Review
Date published: 2015-06-04
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