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Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.
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