Phenylbutazone CAS: 50-33-9
MF: C19H20N2O2
MW: 308.38
An inhibitor of Cox.

Phenylbutazone (CAS 50-33-9)

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Application: An inhibitor of Cox
CAS Number: 50-33-9
Purity: ≥99%
Molecular Weight: 308.38
Molecular Formula: C19H20N2O2
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Phenylbutazone is a compound of research interest as an anti-inflammatory and anti-proliferative agent. Several studies have investigated Phenylbutazone as an anti-inflammatory agent and its role in mediating prostaglandin synthesis. Phenylbutazone may be of interest regarding research into anti-proliferative effects as well, especially in colorectal cancer studies. In studies with human colon cancer cell lines investigating anti-proliferative capabilities of NSAIDs, Phenylbutazone was noted to have intermediate anti-proliferative potency as compared to other NSAIDs. Phenylbutazone is an inhibitor of Cox (cyclooxygenase) that is also a substrate for peroxidation by Cox.


1. Takahashi, M., et al. 1990. Carcinogenesis. 11: 393-395. PMID: 2311181
2. Hixson, L.J., et al. 1994. Cancer Epidemiol. Biomarkers Prev. 3: 433-438. PMID: 7920212
3. Rainsford, K.D. 2007. Subcell. Biochem. 42: 3-27. PMID: 17612044

Physical State :
Solubility :
Soluble in water (1 mg/ml at 25° C), ethanol (62 mg/ml at 25° C), methanol, DMSO (62 mg/ml at 25° C), and DMF (25 mg/ml).
Storage :
Store at room temperature
Melting Point :
106-108° C (lit.)
Boiling Point :
~424.9° C at 760 mmHg (Predicted)
Density :
~1.2 g/cm3 (Predicted)
Refractive Index :
n20D 1.59 (Predicted)
IC50 :
Cox-1: IC50 = 3 µM (human); Cyclooxygenase-2: IC50 = 3.79 µM (Canis lupus familiaris); PGH synthase : IC50 = 10 µM; Plasmodium falciparum 3D7: IC50 = 10 µM; Plasmodium falciparum D10: IC50 = 12.59 µM
Ki Data :
CYP2C9: Ki= 19 µM (human); OAT3: Ki= 34.7 µM (human); AZT glucuronidation: Ki= 1.4 mM (human); Codeine glucuronidation: Ki= 1.7 mM
pK Values :
pKa: 4.64 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
PubChem CID :
Merck Index :
14: 7277
MDL Number :
EC Number :
Beilstein Registry :

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Phenylbutazone  Product Citations

See how others have used Phenylbutazone. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 21348489  Mironov, GG. et al. 2011. Analytical chemistry. 83: 2364-70.

Citations 1 to 1 of 1 total
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