PhenoxybenzamineCAS: 63-92-3
MF: C18H22ClNO·HCl
MW: 340.29
A non-specific irreversible adrenergic (AR) antagonist.

Phenoxybenzamine (CAS 63-92-3)

Phenoxybenzamine | CAS 63-92-3 is rated 5.0 out of 5 by 1.
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Application: A non-specific irreversible adrenergic (AR) antagonist
CAS Number: 63-92-3
Purity: 95%
Molecular Weight: 340.29
Molecular Formula: C18H22ClNO·HCl
* Refer to Certificate of Analysis for lot specific data (including water content).
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Phenoxybenzamine is a cell-permeable, non-specific, irreversible AR (α-adrenergic) antagonist that also acts as an CaM inhibitor. Phenoxybenzamine inhibits calmodulin-stimulated phosphodiesterase activity. This product has been shown to inhibit cGMP accumulation in cerebellar cells evoked by an exogenous nitric oxide donor. Phenoxybenzamine has been used to generate a novel glucocorticoid receptor that complexes with HSP90, but has no hormone binding ability. This compound has also been employed to block high levels of catecholamines.


References

1. Earl, C.Q., et al. 1984. Life Sci. 35: 525-534. PMID: 6146911

2. Ning, Y.M., et al. 1996. Mol. Endocrinol. 10: 14-23. PMID: 8838141

3. Frang, H., et al. 2001. J. Biol. Chem. 276: 31279-31284. PMID: 11395517

4. Chew, S.L. 2004. Expert Opin Investig Drugs. 13: 1579-1583. PMID: 15566315

5. James, L.R., et al. 2009. Br. J. Pharmacol. 158: 1454-1464. PMID: 19845679

Physical State :
Solid
Solubility :
Soluble in water (slightly), ethanol, chloroform, and propylene glycol.
Storage :
Store at 4° C
Melting Point :
136.1-141.1° C
Boiling Point :
381.5° C at 760 mmHg (Predicted)
pK Values :
pKb: 6.58
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
DP3750000
PubChem CID :
5284441
Merck Index :
14: 7256
MDL Number :
MFCD00055152
EC Number :
200-569-7
Beilstein Registry :
3747029
SMILES :
CC(COC1=CC=CC=C1)N(CCCl)CC2=CC=CC=C2.Cl

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Certificate of Analysis

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Phenoxybenzamine  Product Citations

See how others have used Phenoxybenzamine. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 28503132  Majumder, P. et al. 2017. Front Cell Neurosci. 11: 94.

PMID: # 11809715  Benning, CM. et al. 2002. Cancer Res. 62: 597-602.

PMID: # 10092629  Niswender, CM. et al. 1999. J. Biol. Chem. 274: 9472-9478.

Citations 1 to 3 of 3 total
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Rated 5 out of 5 by from Benning et al Benning et al. (PubMed ID 11809715) used Phenoxybenzamine to irreversibly inhibit the alpha1-adrenoreceptor s capacity to bind to norepinephrine. This inactivation of the the receptor did not affect cellular response to doxazosin-induced apoptosis in prostate cancer cells. -SCBT Publication Review
Date published: 2015-03-29
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