Phenol Red is a compound widely used in culture media which identifies pH changes from neutral (red) to acidic (yellow) values. Typically a change in color from red to yellow indicates high rates of cellular death when used in tissue cultures. In the culture of breast cancer cells Phenol Red has been observed to act as a weak estrogen. In human MCF-7 cells, phenol red has reduced Roscovitine (sc-24002) mediated cell cycle arrest and apoptosis. Phenol red has also induced oogenesis from cells scraped from the surface of adult ovaries.
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