Phenamil methanesulfonate (free base)An amiloride analog that irreversibly blocks amiloride-sensitive Na+ channels.

Phenamil methanesulfonate (free base) (CAS 2038-35-9)

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Application: An amiloride analog that irreversibly blocks amiloride-sensitive Na+ channels.
CAS Number: 2038-35-9
Molecular Weight: 401.8
Molecular Formula: C12H12ClN7O•CH3SO3H
* Refer to Certificate of Analysis for lot specific data (including water content).
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Phenamil methanesulfonate (free base) is an amiloride analog. Irreversibly blocks ENaC (amiloride-sensitive Na+ channels).


References

1. Garvin, J.L., et al. 1985. J. Membr. Biol. 87: 45-54. PMID: 2414446
2. Barbry, P., et al. 1989. Biochemistry. 28: 3744-3749. PMID: 2546581
3. Voilley, N., et al 1994. Proc. Natl .Acad. Sci. U.S.A. 91: 247-251. PMID: 8278374

Physical State :
Solid
Solubility :
Soluble in water (partly), DMSO (15 mg/ml), and 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (2.5 mg/ml). Insoluble in 0.1 M HCl, and dilute aquueous acid .
Storage :
Store at 4° C
Melting Point :
258-260° C
Boiling Point :
621.7° C at 760 mmHg (Predicted) (tautomer)
Refractive Index :
n20D 1.76 (Predicted)
IC50 :
Plasmodium falciparum: IC50 = 6.31 µM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9604979
MDL Number :
MFCD00274070
SMILES :
CS(=O)(=O)O.C1=CC=C(C=C1)NC(=NC(=O)C2=C(N=C(C(=N2)Cl)N)N)N

Download SDS (MSDS)

Certificate of Analysis

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