PHCCCMF: C17H14N2O3
MW: 294.30
A group I metabotropic glutamate receptor antagonist.

PHCCC

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Application: A group I metabotropic glutamate receptor antagonist
Molecular Weight: 294.30
Molecular Formula: C17H14N2O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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PHCCC has been shown to act as a group I metabotropic glutamate receptor antagonist with an IC50 of approximately 3 µM. This activity is 67 times more potent than (S)-4-carboxyphenylglycine (sc-203449). This compound has also demonstrated positive allosteric modulation for mGluR-4a, potentiates L-AP4-mediated inhibition of striatopallidal synaptic transmission in vitro, and displays anti-Parkinsonian effects in rat models.

Solubility :
Soluble to 100 mM in DMSO
Storage :
Store at room temperature
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5866327
SMILES :
C1C\2C1(OC3=CC=CC=C3/C2=N/O)C(=O)NC4=CC=CC=C4

Download SDS (MSDS)

Certificate of Analysis

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