PhalloidinAn F-actin stabilizing toxin

Phalloidin (CAS 17466-45-4)

Phalloidin | CAS 17466-45-4 is rated 5.0 out of 5 by 1.
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Synonym: Amanita phalloides Group I toxin
Application: An F-actin stabilizing toxin
CAS Number: 17466-45-4
Purity: ≥90%
Molecular Weight: 788.9
Molecular Formula: C35H48N8O11S
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Phalloidin is a heptapeptide phallotoxin produced by Amanita phalloides, the death cap mushroom. Phalloidin binds and stabilizes filamentous F-actin, preventing the dissociation of paired filaments and disturbing the natural equilibrium between filamentous (polymeric) and globular (monomeric) actin in the cell. Actin is used by the cell for mechanical processes such as growth, scaffolding of the cytoskeleton, and locomotion, and disruption of this actin equilibrium destroys cellular functioning.


References

1. Wehland, J., et al. 1977. Proc. Natl. Acad. Sci. U.S.A. 74: 5613-5617. PMID: 341163
2. Barden, J.A., et al. 1987. Eur. J. Biochem. 162: 583-588. PMID: 3830158
3. Cooper, J.A., 1987. J. Cell Biol. 105: 1473-1478. PMID: 3312229

Physical State :
Solid
Derived From :
Amanita phalloides mushrooms
Solubility :
Soluble in methanol, ethanol (10 mg/ml), water (1 mg/ml, warm), and DMF.
Storage :
Store at 4° C
Melting Point :
280-282° C(.6H2O)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
SE9800000
PubChem CID :
4752
Merck Index :
14: 7196
MDL Number :
MFCD03427567
EC Number :
241-484-5
Beilstein Registry :
Beil. 27,IV,9729
SMILES :
CC1C(=O)NC2CC3=C(NC4=CC=CC=C34)SCC(C(=O)N5CC(CC5C(=O)N1)O)NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CC(C)(CO)O)C)C(C)O

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Certificate of Analysis

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Phalloidin  Product Citations

See how others have used Phalloidin. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 10 total

PMID: # 29619899  Ren, H. et al. 2018. Ren Fail. 40: 273-279.

PMID: # 19964171  Tandon, N. et al. 2009. Conf Proc IEEE Eng Med Biol Soc. 2009: 6517-6521.

PMID: # 17965414  Forgacs, E. et al. 2008. J. Biol. Chem. 283: 766-773.

PMID: # 17502619  Ji, Y. et al. 2007. Proc. Natl. Acad. Sci. U.S.A. 104: 8839-8844.

PMID: # 17337909  Baumgartner, W. et al. 2007. J. Vasc. Res. 44: 234-240.

PMID: # 15620683  Visegrády, B. et al. 2005. FEBS Lett. 579: 6-10.

PMID: # 7669759  Heidecker, M. et al. 1995. Biochemistry. 34: 11017-11025.

PMID: # 1755835  Le Bihan, T. et al. 1991. Biochem. Biophys. Res. Commun. 181: 542-547.

PMID: # 2393669  Dancker, P. et al. 1990. Biochim. Biophys. Acta. 1035: 197-200.

PMID: # 4065095  Vandekerckhove, J. et al. 1985. EMBO J. 4: 2815-2818.

Citations 1 to 10 of 10 total
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Rated 5 out of 5 by from Tandon et al Tandon et al. (PubMed ID 19964171) used Phalloidin, an F-actin stabilizing toxin, to visualize structural changes associated with direct-current stimulation in human adipose tissue-derived stem cells (hASCs). -SCBT Publication Review
Date published: 2015-05-05
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