PGP-4008A selective P-glycoprotein inhibitor

PGP-4008 (CAS 365565-02-2)

PGP-4008 | CAS 365565-02-2 is rated 5.0 out of 5 by 1.
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Application: A selective P-glycoprotein inhibitor
CAS Number: 365565-02-2
Purity: ≥98%
Molecular Weight: 393.5
Molecular Formula: C26H23N3O
* Refer to Certificate of Analysis for lot specific data (including water content).
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PGP-4008 is a selective P-glycoprotein (Pgp)inhibitor. It effectively reverses Pgp mediated drug resistance in NCI/ADR cells, but has no effect on the drug sensitivities of MCF-7/VP cells that overexpress MRP1.


References

B.D. Lee, et al.; Oncol. Res. 14, 49 (2003). B.D. Lee, et al.; J. Med. Chem. 47, 1413 (2004).

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in methanol, 100%ethanol (3 mg/ml), and DMSO (20 mg/ml).
Storage :
Store at -20° C
Melting Point :
261.3° C (Predicted)
Boiling Point :
~678.4° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.71 (Predicted)
pK Values :
pKa: 13.63 (Predicted), 7.22 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
9821937
MDL Number :
MFCD03452998
SMILES :
C1CN(C2=NC3=CC=CC=C3C(=C21)NC(=O)CC4=CC=CC=C4)CC5=CC=CC=C5

Download SDS (MSDS)

Certificate of Analysis

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Rated 5 out of 5 by from Miettinen et al Miettinen et al. (Pubmed ID 19262372) found that the P-gp inhibitor, PGP-4008, potentiated docetaxel-mediated growth inhibition and apoptosis in ovarian cancer cells. -SCBT Publication Review
Date published: 2015-02-18
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