PGP-4008 is a selective P-glycoprotein (Pgp)inhibitor. It effectively reverses Pgp mediated drug resistance in NCI/ADR cells, but has no effect on the drug sensitivities of MCF-7/VP cells that overexpress MRP1.
B.D. Lee, et al.; Oncol. Res. 14, 49 (2003). B.D. Lee, et al.; J. Med. Chem. 47, 1413 (2004).
Soluble in methanol, 100%ethanol (3 mg/ml), and DMSO (20 mg/ml).
Store at -20° C
261.3° C (Predicted)
~678.4° C at 760 mmHg (Predicted)
~1.3 g/cm3 (Predicted)
n20D 1.71 (Predicted)
pKa: 13.63 (Predicted), 7.22 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Miettinen et alMiettinen et al. (Pubmed ID 19262372) found that the P-gp inhibitor, PGP-4008, potentiated docetaxel-mediated growth inhibition and apoptosis in ovarian cancer cells. -SCBT Publication Review
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