PGF1alpha (Prostaglandin F1alpha)A smooth muscle relaxant and a stable metabolite of prostacyclin (PGI2)

PGF1α (Prostaglandin F1α) (CAS 745-62-0)

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Application: A smooth muscle relaxant and a stable metabolite of prostacyclin (PGI2)
CAS Number: 745-62-0
Molecular Weight: 356.5
Molecular Formula: C20H36O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Prostaglandin F1α (PGF1α) is a biosynthesis product from dihomo-γ-linolenic acid (DGLA) via the cyclooxygenaze (COX) pathway, and is a stable metabolite of prostacyclin (PGI2; sc-201231). By measuring the olfactory sensitivity of male salmon to F-type prostaglandins, studies show there is a possibility that they have a pheromonal role in Atlantic salmon. This compound also acts as smooth muscle relaxant, however, PGF1α is only half as active as PGF2α (sc-201227) in inducing human respiratory smooth muscle contractions in vitro.


References

1. Karim, S.M., et al. 1980. Adv Prostaglandin Thromboxane Res. 7: 969-980. PMID: 7369062
2. Herndon, D.N., et al. 1984. Surg Gynecol Obstet. 159: 210-213. PMID: 6433494
3. Balapure, A.K., et al. 1989. Biochem. Pharmacol. 38: 2375-2381. PMID: 2751699
4. Moore, A. 1996. J. Exp. Biol. 199: 2307-2316. PMID: 9320226
5. Bertone, A.L., et al. 2001. Vet Surg. 30: 528-538. PMID: 11704948

Physical State :
Solid
Solubility :
Soluble in ethanol (50 mg/ml), water (>2 mg/ml) at 25° C, PBS (pH 7.2) (2.1 mg/ml), DMSO (50 mg/ml), and DMF (50 mg/ml).
Storage :
Store at -20° C
Melting Point :
95-97° C
Boiling Point :
~526.6° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.56
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GY4569700
PubChem CID :
5280939
MDL Number :
MFCD00077862
Beilstein Registry :
2704846
SMILES :
CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1CCCCCCC(=O)O)O)O)O

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Certificate of Analysis

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