PGE2CAS: 363-24-6
MF: C20H32O5
MW: 352.47
An extremely important eicosanoid involved in neuronal, metabolic, and immune system function.

PGE2 (CAS 363-24-6)

PGE2 | CAS 363-24-6 is rated 5.0 out of 5 by 1.
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Synonym: Prostaglandin E2; Dinoprostone; (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxo-prosta-5,13-dien-1oic acid
Application: An extremely important eicosanoid involved in neuronal, metabolic, and immune system function
CAS Number: 363-24-6
Purity: ≥98%
Molecular Weight: 352.47
Molecular Formula: C20H32O5
* Refer to Certificate of Analysis for lot specific data (including water content).
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Prostaglandin E2 (PGE2) is the most physiologically abundant eicosanoid, which is produced predominantly from arachidonic acid (sc-200770) by COX and PGES, and exists at some level in nearly all cell types. PGE2 acts on four different receptors termed EP1 through EP4 yielding an astounding array of biological effects. Reported effects include: potent vasodilation, smooth muscle relaxation, both anti- and pro-inflammatory activities, stimulates bone resorption, synergizes with LTB4, facilitates replication of AIDS virus, regulates sleep/wake cycle, demonstrates thermoregulatory action in the CNS, induces LHRH release from rat median eminence, demonstrates a protective effect on gastric mucosa, and regulates renal hemodynamics and sodium excretion.


References

1. Raisz, L G., et al., 1977. Effect of prostaglaidin endoperoxides and metabolites on bone resorption in vitro. Nature. 267(5611): 532-4. PMID: 876371
2. Richardson, P D., et al., 1976. The vasodilator actions of isoprenaline, histamine, prostaglandin E2, glucagon and secretin on the hepatic arterial vascular bed of the dog. British journal of pharmacology. 57(4): 581-8. PMID: 963344
3. Christman, J W., et al., 1991. Paradoxical regulation by PGE-2 on release of neutrophil chemoattractants by rat bone marrow macrophages. Prostaglandins. 41(3): 251-62. PMID: 1852897
4. Gerozissis, K., et al., 1991. Prostaglandin E2 and leukotriene C4-induced luteinizing hormone-releasing hormone release from immature and adult male rat median eminences in vitro: eicosanoid formation and binding parameters. Prostaglandins. 41(4): 345-57. PMID: 1871376
5. Long, C R., et al., 1990. Prostaglandin E2 induced changes in renal blood flow, renal interstitial hydrostatic pressure and sodium excretion in the rat. Prostaglandins. 40(6): 591-601. PMID: 2093936
6. Raud, J., et al., 1988. Enhancement of acute allergic inflammation by indomethacin is reversed by prostaglandin E2: apparent correlation with in vivo modulation of mediator release. Proceedings of the National Academy of Sciences of the United States of America. 85(7): 2315-9. PMID: 2451246
7. Archer, C B., et al., 1987. Delayed-onset synergism between leukotriene B4 and prostaglandin E2 in human skin. Prostaglandins. 33(6): 799-805. PMID: 2823313
8. Kuno, S., et al., 1986. Prostaglandin E2, a seminal constituent, facilitates the replication of acquired immune deficiency syndrome virus in vitro. Proceedings of the National Academy of Sciences of the United States of America. 83(10): 3487-90. PMID: 3010301
9. Hayaishi, O., et al., 1988. Sleep-wake regulation by prostaglandins D2 and E2. The Journal of biological chemistry. 263(29): 14593-6. PMID: 3049580
10. Kuno, S., et al., 1986. Prostaglandin E2 administered via anus causes immunosuppression in male but not female rats: a possible pathogenesis of acquired immune deficiency syndrome in homosexual males. Proceedings of the National Academy of Sciences of the United States of America. 83(8): 2682-3. PMID: 3458226
11. Miller, T A., et al., 1983. Protective effects of prostaglandins against gastric mucosal damage: current knowledge and proposed mechanisms. The American journal of physiology. 245(5 Pt 1): G601-23. PMID: 6195926

Physical State :
Solid
Solubility :
Soluble in acetone, ethanol (50 mg/ml), DMSO (50 mg/ml), water (Partly miscible), DMF (100 mg/ml), PBS, pH 7.2 (5 mg/ml), and ethyl acetate.
Storage :
Store at -20° C
Melting Point :
67-69° C
Boiling Point :
530.07° C at 760 mmHg
Density :
1.15 g/cm3
Refractive Index :
n20D 1.56
Optical Activity :
α20/D -85.5°, c = 1 in ethanol
IC50 :
MAP kinase: IC50 = 25-50 µM (rat mesangial cells)
pK Values :
pKa: 4.76
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
UK8000000
PubChem CID :
9691
Merck Index :
14: 7877
MDL Number :
MFCD00077861
EC Number :
206-656-6
Beilstein Registry :
4709356
SMILES :
CCCCC[C@@H](C=C[C@H]1[C@@H](CC(=O)[C@@H]1CC=CCCCC(=O)O)O)O

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Certificate of Analysis

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PGE2  Product Citations

See how others have used PGE2. Click on the entry to view the PubMed entry .

Citations 1 to 10 of 15 total

PMID: # 31097693  Zhan, T.|Ambrosi, G.|Wandmacher, AM.|Rauscher, B.|Betge, J.|Rindtorff, N.|Häussler, RS.|Hinsenkamp, I.|Bamberg, L.|Hessling, B.|Müller-Decker, K.|Erdmann, G.|Burgermeister, E.|Ebert, MP.|Boutros, M.| et al. 2019. Nat Commun. 10: 2197.

PMID: # 29095955  Matsubara, S.|Shiraishi, A.|Sakai, T.|Okuda, T.|Satake, H.| et al. 2017. PLoS ONE. 12: e0187711.

PMID: # 29354056  Fiore, D.|Ramesh, P.|Proto, MC.|Piscopo, C.|Franceschelli, S.|Anzelmo, S.|Medema, JP.|Bifulco, M.|Gazzerro, P.| et al. 2017. Front Pharmacol. 8: 949.

PMID: # 28892080  Zhuang, X.|Zhang, H.|Li, X.|Li, X.|Cong, M.|Peng, F.|Yu, J.|Zhang, X.|Yang, Q.|Hu, G.| et al. 2017. Nat. Cell Biol. 19: 1274-1285.

PMID: # 26610166  Nilsson, M. et al. 2016. Scandinavian journal of gastroenterology. 51: 538-47.

PMID: # 27020962  Bender, BF. et al. 2016. Lab on a chip. 16: 1505-13.

PMID: # 25510471  Aijian, AP. et al. 2015. Journal of laboratory automation. 20: 283-95.

PMID: # 24505138  He, L. et al. 2014. The Journal of biological chemistry. 289: 8019-28.

PMID: # 25184246  Dolkart, O. et al. 2014. The American journal of sports medicine. 42: 2869-76.

PMID: # 24586238  Clemente, MI. et al. 2014. PLoS ONE. 9: e85230.

Citations 1 to 10 of 15 total

Is this product cell culture tested?

Asked by: TESA
This product has not been specifically tested for cell culture use and is not cell culture grade, however, most products can still be used in cell culture applications by following basic cell culture protocols, e.g. using cell culture grade/sterilized solvents, aseptic technique, and sterilely filtering in a sterile hood.
Answered by: Technical Support
Date published: 2018-11-30

Is this prepared as an injectable?

Asked by: Pbellones
Thank you for your question. This biochemical is provided as a solid. Our compounds are not pharmaceutical grade and not manufactured under GMP guidelines. Please consult your principal investigator and your animal care and use committee (ACUC) regarding the use of our compounds. If you have any further questions, please contact our Asia Technical Service team. You can reach them by phone at (86 21) 6093-6350, by email at: asia@scbio.cn or by live chat directly on our website, www.scbt.com
Answered by: Tech Service
Date published: 2018-01-18

What is the source (synthetic/animal) of the compound?

Asked by: two2igm05
Thank you for your question. PGE2, sc-201225, is synthetic.
Answered by: Chemical Support 4
Date published: 2017-04-19

What is the expected appearance of this product?

Asked by: chemicalsmg
Thank you for your question. PGE2: sc-201225 is expected to be a white to pale yellow solid.
Answered by: Chemical Support 3
Date published: 2017-03-24

 Is this substance synthetic or from animal origin? 

Asked by: SCM4
This is supplied as synthetic PGE2.
Answered by: Tech Service 11
Date published: 2017-03-17

Is this product lyophilized?

Asked by: SCM4
The product is a crystalized solid, but, No, it has not been lyophilized.
Answered by: Tech Service 11
Date published: 2017-03-17
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Rated 5 out of 5 by from Charo et al Charo et al. (PubMed ID 23090667) found that PGE2 (prostaglandin E2), a key eicosanoid involved in neural, metabolic, and immune system function, regulated pancreatic stellate cell profibrotic activity via the EP4 receptor. -SCBT Publication Review
Date published: 2015-05-13
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