Every item is shipped based on the best shipping method assessed for the temperature requirements of that specific item. Items are grouped and shipped together whenever
possible, and a separate shipping charge will be included for each shipping method required. Shipping charges listed below are from our US warehouses to the Contiguous US,
Alaska, Hawaii, Canada and Puerto Rico. Shipping charges for countries outside the US and Canada will be determined once order has been received
Please note: We can not ship to PO boxes
Express Blue Ice
Express Dry Ice
Animal Health Prescription Item
SHIPPING METHODS & CHARGES
Ships via FedEx Ground to Contiguous US, Alaska, Canada, Monday through Friday. This method is used for less temperature sensitive items such as lab ware and animal
health products, bulky and/or heavy items
Labware ships FedEx Ground free of charge to the contiguous US
Transcription factors exert their effects by associating with co-activator or corepressor proteins. The co-activator complexes are thought to be constitutively active, requiring only proper positioning in the genome to initiate transcription. Co-activators include the steroid receptor coactivator (SRC) and CREB binding protein (CBP) families that contain histone acetyltransferase (HAT) activity, which modifies chromatin structure. PPARgamma co-activator-1 (PGC-1) is a transcriptional cofactor of nuclear respiratory factor-1 (NRF-1), PPARbeta, PPARalpha and other nuclear receptors that is induced by exposure to cold temperatures and is involved in regulating thermogenic gene expression, protein uncoupling, and mitochondrial biogenesis. PGC-1 has a low inherent transcriptional activity when it is not bound to a transcription factor. Docking of PGC-1 to PPARgamma stimulates an apparent conformational change that then enables PGC-1 to bind to and assemble into complexes, which include the additional cofactors SRC-1 and CBP/p300, and results in a large increase in transcriptional activity.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.