PGA1 (Prostaglandin A1) is an anti-inflammatory cyclopentenone prostaglandin, biosynthesized from dihomo-γ-linolenic acid, and was originally discovered as a dehydration product of PGE1 (sc-201223). PGA1 has been shown to cause renal vasodilation, stimulate renin release, inhibit NFκB activation, activate PPARs, and induce thermotolerance through modulation of heat shock protein 70. Furthermore this product has been shown to inhibit the proliferation of tumor cells with an IC50 = 7.5 μM for ovarian tumor cell cultures.
1. Hahn, J., et al. 1980. Prostaglandins. 20: 15-23. PMID: 6996036 2. Marini, S., et al. 1990. Br. J. Cancer. 61: 394-399. PMID: 2328205 3. Amici, C., et al. 1993. Exp. Cell Res. 207: 230-234. PMID: 8344376 4. Yu, K., et al. 1995. J. Biol. Chem. 270: 23975-23983. PMID: 7592593 5. Elia, G., et al. 1996. Cancer Res. 56: 210-217. PMID: 8548766 6. Rossi, A., et al. 1997. Proc. Natl. Acad. Sci. U.S.A. 94: 746-750. PMID: 9012856 7. Rossi, A., et al. 2000. Nature. 403: 103-108. PMID: 10638762
Soluble in 100%ethanol (50 mg/ml), DMSO (50 mg/ml), and PBS pH7.2 (2.4 mg/ml).
Store at -20° C
~510.7° C at 760 mmHg (Predicted)
~1.1 g/cm3 (Predicted)
ovarian cancer: IC50 = 7.5 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Rossi et alRossi et al. (PubMed ID 9012856) found that PGA1 (Prostaglandin A1) is a strong inhibitor of nuclear factor-kappa B (NF-kappa B) activation in human cells and of NF-kappa B-dependent HIV-1 transcription by inhibiting phosphorylation and preventing degradation of the NF-kappa B inhibitor I kappa B-alpha. -SCBT Publication Review
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