PGA1 (Prostaglandin A1)A potent anti-inflammatory cyclopentenone prostaglandin demonstrating inhibition of NFκB

PGA1 (Prostaglandin A1) (CAS 14152-28-4)

PGA1 (Prostaglandin A1) | CAS 14152-28-4 is rated 5.0 out of 5 by 1.
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Synonym: 9-oxo-15S-hydroxy-prosta-10,13E-dien-1-oic acid
Application: A potent anti-inflammatory cyclopentenone prostaglandin demonstrating inhibition of NFκB
CAS Number: 14152-28-4
Purity: ≥98%
Molecular Weight: 336.5
Molecular Formula: C20H32O4
* Refer to Certificate of Analysis for lot specific data (including water content).
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PGA1 (Prostaglandin A1) is an anti-inflammatory cyclopentenone prostaglandin, biosynthesized from dihomo-γ-linolenic acid, and was originally discovered as a dehydration product of PGE1 (sc-201223). PGA1 has been shown to cause renal vasodilation, stimulate renin release, inhibit NFκB activation, activate PPARs, and induce thermotolerance through modulation of heat shock protein 70. Furthermore this product has been shown to inhibit the proliferation of tumor cells with an IC50 = 7.5 μM for ovarian tumor cell cultures.


References

1. Hahn, J., et al. 1980. Prostaglandins. 20: 15-23. PMID: 6996036
2. Marini, S., et al. 1990. Br. J. Cancer. 61: 394-399. PMID: 2328205
3. Amici, C., et al. 1993. Exp. Cell Res. 207: 230-234. PMID: 8344376
4. Yu, K., et al. 1995. J. Biol. Chem. 270: 23975-23983. PMID: 7592593
5. Elia, G., et al. 1996. Cancer Res. 56: 210-217. PMID: 8548766
6. Rossi, A., et al. 1997. Proc. Natl. Acad. Sci. U.S.A. 94: 746-750. PMID: 9012856
7. Rossi, A., et al. 2000. Nature. 403: 103-108. PMID: 10638762

Physical State :
Solid
Solubility :
Soluble in 100%ethanol (50 mg/ml), DMSO (50 mg/ml), and PBS pH7.2 (2.4 mg/ml).
Storage :
Store at -20° C
Melting Point :
195.46° C
Boiling Point :
~510.7° C at 760 mmHg (Predicted)
Density :
~1.1 g/cm3 (Predicted)
Refractive Index :
n20D 1.54
IC50 :
ovarian cancer: IC50 = 7.5 µM (human)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
GY5977900
PubChem CID :
5281912
MDL Number :
MFCD00077858
EC Number :
234-237-8
Beilstein Registry :
2003401
SMILES :
CCCCC[C@@H](/C=C/[C@H]1C=CC(=O)[C@@H]1CCCCCCC(=O)O)O

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Certificate of Analysis

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PGA1 (Prostaglandin A1)  Product Citations

See how others have used PGA1 (Prostaglandin A1). Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28112176  Su, AR. et al. 2017. Acta Pharmacol. Sin. 38: 402-414.

Citations 1 to 1 of 1 total
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Rated 5 out of 5 by from Rossi et al Rossi et al. (PubMed ID 9012856) found that PGA1 (Prostaglandin A1) is a strong inhibitor of nuclear factor-kappa B (NF-kappa B) activation in human cells and of NF-kappa B-dependent HIV-1 transcription by inhibiting phosphorylation and preventing degradation of the NF-kappa B inhibitor I kappa B-alpha. -SCBT Publication Review
Date published: 2015-02-22
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