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PETCM | CAS 10129-56-3 | SCBT - Santa Cruz Biotechnology
PETCM CAS: 10129-56-3
MF: C8H8Cl3NO
MW: 240.5
A caspace-3 activator in cell extracts.

PETCM (CAS 10129-56-3)

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Application: PETCM is a caspace-3 activator in cell extracts
CAS Number: 10129-56-3
Purity: ≥95%
Molecular Weight: 240.5
Molecular Formula: C8H8Cl3NO
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols. In addition, studies suggest that PETCM can reverse the inhibitory effects of putative HLA-DR-associated proteins (PHAP) on caspase-3 activation. Since caspase-3 activation is dependent on apoptosome formation, prothymosin α can inhibit the activation of caspase-3 by disrupting the formation of the apoptosome somewhere upstream in this regulatory pathway. Studies suggest that PETCM can eliminate the inhibitory effects of prothymosin α by acting as an antagonist and allwing PHAP to stimulate apoptosome formation at a physiological concentration of deoxyadenosine triphosphate.


References

1. Jiang, X., et al. 2003. Science. 299: 223-226. PMID: 12522243

Appearance :
Powder
Physical State :
Solid
Solubility :
Soluble in DMF, DMSO (22 mg/ml), methanol (25 mg/ml), and 1eq. HCl (50 mM). Insoluble in water.
Storage :
Store at 4° C
Melting Point :
164° C
Boiling Point :
342.21° C at 760 mmHg (Predicted)
Density :
1.47 g/cm3 (Predicted)
Refractive Index :
n20D 1.58 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00177920
SMILES :
C1=CN=CC=C1CC(C(Cl)(Cl)Cl)O

Download SDS (MSDS)

Certificate of Analysis

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