Pertussis Toxin (islet-activating protein) CAS: 70323-44-3
A toxin that blocks reduction of adenylate cyclase activity.

Pertussis Toxin (islet-activating protein) (CAS 70323-44-3)

Pertussis Toxin (islet-activating protein) | CAS 70323-44-3 is rated 5.0 out of 5 by 1.
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Alternate Names: PTX;Holotoxin
Application: Pertussis Toxin (islet-activating protein) is a toxin that blocks reduction of adenylate cyclase activity
CAS Number: 70323-44-3
Purity: >99%
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pertussis Toxin (islet-activating protein), a toxin originally isolated from Bordetella pertussis, has been shown to catalyze ADP-ribosylation of a protein in membrane preparation from rat C6 glioma cells. In addition, exposure of Chinese hamster ovary cells in culture to this compound has resulted in a clustered growth pattern response. Other experiments have shown Pertussis Toxin to block the ability of inhibitory hormones to reduce adenylate cyclase activity and enhance the ability of stimulatory hormones to activate the enzyme. Mechanistic studies have shown this toxin to consist of subunit A (active) promoter, which disrupts transmembrane signaling by ADP-ribosylating eukaryotic G-proteins, and B (binding) oligomer which helps the toxin bind to cells in vivo.


References

1. Tamura, M., et al. 1982. Biochemistry. 21: 5516-5522. PMID: 6293544
2. Hewlett, E.L., et al. 1983. Infect. Immun. 40: 1198-1203. PMID: 6682833
3. Bokoch, G.M., et al. 1983. J. Biol. Chem. 258: 2072-2075. PMID: 6296122
4. Kaslow, H.R., et al. 1987. Biochemistry. 26: 123-127. PMID: 3030399
5. Kaslow, H.R. and Burns, D.L. 1992. FASEB J. 6: 2684-2690. PMID: 1612292

Physical State :
Solid
Derived From :
Bordetella pertussis
Solubility :
Soluble in water (Miscible).
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XW5883750
MDL Number :
MFCD00131841

Download SDS (MSDS)

Certificate of Analysis

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Pertussis Toxin (islet-activating protein) (CAS 70323-44-3)  Product Citations

See how others have used Pertussis Toxin (islet-activating protein) (CAS 70323-44-3). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 33746958  Alonso, S.|Vidal, M.|Ruiz-Olalla, G.|González, R.|Manaca, MN.|Jairoce, C.|Vázquez-Santiago, M.|Balcells, R.|Vala, A.|Rupérez, M.|Cisteró, P.|Fuente-Soro, L.|Cova, M.|Angov, E.|Nhacolo, A.|Sevene, E.|Aponte, JJ.|Macete, E.|Aguilar, R.|Mayor, A.|Menéndez, C.|Dobaño, C.|Moncunill, G.| et al. 2021. Front Immunol. 12: 614246.

PMID: # 3158374  Fujita, N. et al. 1985. Brain Res. 333: 231-236.

Citations 1 to 2 of 2 total

hi just need to know molecular weight of this pertussis, because i want to dilute to have 200 ng/ml thank you

Asked by: smel2377
Thank you for your question. The molecular weight is lot dependent, but here is a link to a recent CoA, which contains the molecular weight information. https://datasheets.scbt.com/coa/coa.php?sc=sc-200837&lot=F1119
Answered by: Tech Service
Date published: 2019-08-15
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Rated 5 out of 5 by from Fujita et al Fujita et al. (PubMed ID 3158374) found that the Pertussis Toxin (islet-activating protein) blocked the adenylate cyclase system and directly interacted with the D2-dopamine receptor. -SCBT Publication Review
Date published: 2015-02-24
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