PentoxifyllineA non-selective phosphodiesterase inhibitor. Inhibits endotoxin-induced synthesis of TNF-α

Pentoxifylline (CAS 6493-05-6)

Pentoxifylline | CAS 6493-05-6 is rated 5.0 out of 5 by 1.
  • y_2019, m_11, d_17, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203184, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 98ms
  • REVIEWS, PRODUCT
5
1
4
0
3
0
2
0
1
0
Synonym: Trental; Oxpentifylline
Application: A non-selective phosphodiesterase inhibitor. Inhibits endotoxin-induced synthesis of TNF-α
CAS Number: 6493-05-6
Purity: ≥99%
Molecular Weight: 278.31
Molecular Formula: C13H18N4O3
* Refer to Certificate of Analysis for lot specific data (including water content).
Submit a review for this product and receive 15 CruzCredits

Pentoxifylline is a non-selective PDE (phosphodiesterase) inhibitor. Inhibits endotoxin-induced synthesis of tumor necrosis factor-a (TNF α). PTX inhibits the adhesion of T cells to the b1 and b2 Integrin ligands VCAM-1 and ICAM-1. Also prevents the down-regulation of microsomal cytochrome P450 caused by lipopolysaccharides.This compound is also a PDE (phosphodiesterase) inhibitor that blocks production of TNF α and other cytokines. Displays antinociceptive activity.


References

Gonzalez-Amaro, R., et al. 1998. J. Immunol. 161, 65. Monshouwer, M., et al. 1996. Biochem. Pharmacol. 52, 1195. Rosenthal, L.A., et al. 1992. J. Interferon. Res. 12, 403. Zabel, P., et al. 1992. Immun. Infekt. 20, 80. Thiel, M., et al. 1991. Biochem. Res. Biophys. Commun. 180, 53

Appearance :
Crystalline
Physical State :
Solid
Derived From :
Penicillium expansum
Solubility :
Soluble in water (≥43 mg/ml), chloroform, methanol, and benzene.
Storage :
Store at room temperature
Melting Point :
104-105° C
Boiling Point :
531.31° C at 760 mmHg (Predicted)
Density :
1.32 g/cm3 (Predicted)
Refractive Index :
n20D 1.62 (Predicted)
IC50 :
interleukin-1-beta (IL1-beta) production: IC50 = >100 µM (human); Effective concentration required in vitro for tracheal muscle: EC5050 = 28.3 µM (guinea pig); TNF-alpha: IC50 = 85 µM (human)
Ki Data :
Adenosine A1-R: Ki= 180 µM (human); Phosphodiesterase 4: Ki= 37.7 µM (human); Adenosine A2B-R: Ki= 5.18 µM (human)
pK Values :
pKb: 0.5 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
XH2475000
PubChem CID :
4740
Merck Index :
14: 7136
MDL Number :
MFCD00063379
EC Number :
229-374-5
SMILES :
CC(=O)CCCCN1C(=O)C2=C(N=CN2C)N(C1=O)C

Download SDS (MSDS)

Certificate of Analysis

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Pentoxifylline  Product Citations

See how others have used Pentoxifylline. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 28587779  Taraji, M. et al. 2017. J Chromatogr A. 1507: 53-62.

Citations 1 to 1 of 1 total
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 68ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
Rated 5 out of 5 by from Banihani et al Banihani et al. (PubMed ID 26395279) found that pentoxifylline enhanced human sperm motility by increasing creatine kinase activity. -SCBT Publication Review
Date published: 2015-04-22
  • y_2019, m_11, d_17, h_20
  • bvseo_bulk, prod_bvrr, vn_bulk_3.0.2
  • cp_1, bvpage1
  • co_hasreviews, tv_0, tr_1
  • loc_en_US, sid_203184, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)]
  • clientName_scbt
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 5ms
  • REVIEWS, PRODUCT

Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2019 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.