Pentoxifylline is a non-selective PDE (phosphodiesterase) inhibitor. Inhibits endotoxin-induced synthesis of tumor necrosis factor-a (TNF α). PTX inhibits the adhesion of T cells to the b1 and b2 Integrin ligands VCAM-1 and ICAM-1. Also prevents the down-regulation of microsomal cytochrome P450 caused by lipopolysaccharides.This compound is also a PDE (phosphodiesterase) inhibitor that blocks production of TNF α and other cytokines. Displays antinociceptive activity.
Gonzalez-Amaro, R., et al. 1998. J. Immunol. 161, 65. Monshouwer, M., et al. 1996. Biochem. Pharmacol. 52, 1195. Rosenthal, L.A., et al. 1992. J. Interferon. Res. 12, 403. Zabel, P., et al. 1992. Immun. Infekt. 20, 80. Thiel, M., et al. 1991. Biochem. Res. Biophys. Commun. 180, 53
Soluble in water (≥43 mg/ml), chloroform, methanol, and benzene.
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