Pentamidine isethionateAn NMDA Glu antagonist and NOS1 inhibitor

Pentamidine isethionate (CAS 140-64-7)

Pentamidine isethionate | CAS 140-64-7 is rated 5.0 out of 5 by 1.
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Synonym: Pentamidine diisethionate; Pentamidine isethionate salt
Application: An NMDA Glu antagonist and NOS1 inhibitor
CAS Number: 140-64-7
Purity: ≥99%
Molecular Weight: 592.68
Molecular Formula: C19H24N4O22C2H6O4S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pentamidine isethionate inhibits constitutive NOS1 in the brain and acts as a NMDA Glu antagonist. Pentamidine isethionate is an antimicrobial and neuroprotective agent.


References

Reynolds and Aizeman (1992) Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro. J. Neurosci. 12 970. Kitamura et al (1995) Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist. Eur.J.Pharmacol. 289 299.

Physical State :
Solid
Solubility :
Soluble in glycerol, and water (100 mM).
Storage :
Store at -20° C
Melting Point :
188-194° C (lit.)
Boiling Point :
539.4° C at 760 mmHg (Predicted)
pK Values :
pKb: 12.50 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CV6500000
PubChem CID :
8813
Merck Index :
14: 7115
MDL Number :
MFCD00079213
EC Number :
205-424-1
Beilstein Registry :
4286775
SMILES :
C1=CC(=CC=C1C(=N)N)OCCCCCOC2=CC=C(C=C2)C(=N)N.C(CS(=O)(=O)O)O.C(CS(=O)(=O)O)O

Download SDS (MSDS)

Certificate of Analysis

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Pentamidine isethionate  Product Citations

See how others have used Pentamidine isethionate. Click on the entry to view the PubMed entry .

Citations 1 to 1 of 1 total

PMID: # 26344166  Zsila, F. et al. 2015. Phys Chem Chem Phys. 17: 24560-5.

Citations 1 to 1 of 1 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. This compound, Pentamidine isethionate (CAS 140-64-7), has an appearance of a white powder.
Answered by: Technical Support
Date published: 2017-01-11
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Rated 5 out of 5 by from Cirillo et al Cirillo et al. (PubMed ID 26295040) found that pentamidine inhibited A -induced gliosis and neuroinflammation in an animal model of Alzheimer's disease. -SCBT Publication Review
Date published: 2015-03-10
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