Pentamidine isethionate inhibits constitutive NOS1 in the brain and acts as a NMDA Glu antagonist. Pentamidine isethionate is an antimicrobial and neuroprotective agent.
Reynolds and Aizeman (1992) Pentamidine is an N-methyl-D-aspartate receptor antagonist and is neuroprotective in vitro. J. Neurosci. 12 970. Kitamura et al (1995) Inhibition of constitutive nitric oxide synthase in the brain by pentamidine, a calmodulin antagonist. Eur.J.Pharmacol. 289 299.
Soluble in glycerol, and water (100 mM).
Store at -20° C
188-194° C (lit.)
539.4° C at 760 mmHg (Predicted)
pKb: 12.50 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Rated 5 out of
Cirillo et alCirillo et al. (PubMed ID 26295040) found that pentamidine inhibited A -induced gliosis and neuroinflammation in an animal model of Alzheimer's disease. -SCBT Publication Review
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