PenciclovirA purine acyclic nucleoside analogue with potent antiviral activity

Penciclovir (CAS 39809-25-1)

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Synonym: 2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin- 6-one
Application: A purine acyclic nucleoside analogue with potent antiviral activity
CAS Number: 39809-25-1
Purity: >98%
Molecular Weight: 253.26
Molecular Formula: C10H15N5O3
* Refer to Certificate of Analysis for lot specific data (including water content).
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Penciclovir is a purine acyclic nucleoside analogue with potent antiviral activity. The compound has been used in Human Herpesvirus 6 studies and its activity assessed through flow cytometry. Herpes simplex virus-1 studies indicate that Penciclovir induces apoptosis without causing much genotoxicity.


References

1. Thust, R., et al. 1996. Antiviral Res. 31: 105-113. PMID: 8793014
2. Thust, R., et al. 2000. Cancer Gene Ther. 7: 107-117. PMID: 10678363
3. Amjad, M., et al. 2001. Microbiol. Immunol. 45: 233-240. PMID: 11345533
4. Leary, J.J., et al. 2002. Antimicrob. Agents Chemother. 46: 762-768. PMID: 11850259

Appearance :
Crystalline
Physical State :
Solid
Solubility :
Soluble in water (1.7 mg/ml) at 20° C, DMSO, and aqueous buffer.
Storage :
Store at -20° C
Melting Point :
272.2-275° C
Boiling Point :
653.4° C at 760 mmHg (Predicted)
Density :
1.69 g/cm3 (Predicted)
Refractive Index :
n20D 1.75 (Predicted)
IC50 :
HHV-6A: IC50 = 37.9 µM; HHV-6B: IC50 = 77.8 µM
pK Values :
pKa: 0.54, pKb: 10.27
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
4725
Merck Index :
14: 7083
MDL Number :
MFCD00866931
SMILES :
C1=NC2=C(N1CCC(CO)CO)NC(=NC2=O)N

Download SDS (MSDS)

Certificate of Analysis

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