Pemetrexed Disodium CAS: 150399-23-8
MF: C20H19N5O6•2Na
MW: 471.37

Pemetrexed Disodium (CAS 150399-23-8)

Pemetrexed Disodium | CAS 150399-23-8 is rated 5.0 out of 5 by 1.
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Alternate Names: Pemetrexed Disodium is known as a Thymidylate synthase inhibitor.
Application: Pemetrexed Disodium is a novel multitargeted antifolate antineoplastic agent and inhibitor of TS, DHFR and GARFT.
CAS Number: 150399-23-8
Purity: ≥98%
Molecular Weight: 471.37
Molecular Formula: C20H19N5O62Na
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).
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Pemetrexed Disodium is a novel, multitargeted, antineoplastic antifolate. In addition, Pemetrexed Disodium is an antimetabolite. Pemetrexed Disodium inhibits DHFR, GARFT, and thymidylate synthase, as well as other folate dependent enzymes. Pemetrexed Disodium is shown to induce autophagy and apoptosis. Pemetrexed Disodium shows antiproliferative activity in CCRF-CEM leukemia, GC3/C1 colon carcinoma, and HCT-8 ileocecal carcinoma cells.


References

1. McDonald, A.C., et al.: Clin. Cancer Res., 4, 605 (1998)
2. John, W., et al.: Cancer, 88, 1807 (2000)
3. Miller, K.D., et al.: Ann. Oncol., 11, 101 (2000)

Physical State :
Solid
Solubility :
Soluble in water (94 mg/ml at 25° C), DMSO (1 mg/ml), ethanol (<1 mg/ml at 25° C), and methanol.
Storage :
Store at -20° C
Melting Point :
255-265° C (dec.)
Refractive Index :
n20D ~1.72 (Predicted)
Ki Data :
TS: Ki= 1.3 nM; DHFR: Ki= 7.2 nM; GARFT: Ki= 65 nM
pK Values :
pKa: 3.58 (Predicted), pKb: 4.54 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
MDL Number :
MFCD07779402
SMILES :
C1=CC(=CC=C1CCC2=CNC3=C2C(=O)N=C(N3)N)C(=O)N[[email protected]@H](CCC(=O)[O-])C(=O)[O-].[Na+].[Na+]

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Certificate of Analysis

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Pemetrexed Disodium (CAS 150399-23-8)  Product Citations

See how others have used Pemetrexed Disodium (CAS 150399-23-8). Click on the entry to view the PubMed entry .

Citations 1 to 5 of 5 total

PMID: # 27287512  Kuryk, L.|Haavisto, E.|Garofalo, M.|Capasso, C.|Hirvinen, M.|Pesonen, S.|Ranki, T.|Vassilev, L.|Cerullo, V.| et al. 2016. Int. J. Cancer. 139: 1883-93.

PMID: # 25639715  Kim, MJ.|Kwon, SB.|Ham, SH.|Jeong, ES.|Choi, YK.|Choi, KD.|Hong, JT.|Jung, SH.|Yoon, DY.| et al. 2015. J Microbiol Biotechnol. 25: 648-57.

PMID: # 26439264  Okita, R. et al. 2015. PloS one. 10: e0139809.

PMID: # 23176546  Ushijima, M. et al. 2013. Cancer Sci. 104: 360-8.

PMID: # 31963196  Molecules. 25:

Citations 1 to 5 of 5 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. Pemetrexed Disodium, sc-219564, is white to light yellow or greenish yellow freeze drying solids.
Answered by: TechService7
Date published: 2017-01-27
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Rated 5 out of 5 by from Hwang Hwang, et al. (PubMed ID 26334320) found that pemetrexed and simvastatin, when used in tandem, heightened apoptosis in malignant mesothelioma and NSCLC cells. -SCBT Publication Review
Date published: 2015-05-28
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