Pefloxacin mesylate dihydrate is an analog of norfloxacin. Fluoroquinolone antibacterial agent and prevents bacterial DNA replication by inhibiting Topo II α (DNA gyrase). Very effective against Staphylococcus aureus, E. coli, other enterobacteria and Pseudomonas aeruginosa. High effect.
Absorption, distribution, metabolic fate, and elimination of pefloxacin mesylate in mice, rats, dogs, monkeys, and humans: G. Montay, et al.; Antimicrob. Agents Chemother. 25, 463 (1984) Activity of pefloxacin and thirteen other antimicrobial agents in vitro against isolates from hospital and genitourinary infections: B.M. Jones, et al.; J. Antimicrob. Chemother. 17, 739 (1986) In vitro activity of pefloxacin against gram-negative and gram-positive bacteria in comparison with other antibiotics: E. Debbia, et al.; Chemioterapia 6, 319 (1987) Studies on prodrugs. 7. Synthesis and antimicrobial activity of 3-formylquinolone derivatives: H. Kondo, et al.; J. Med. Chem. 31, 221 (1988) In vitro effects of ciprofloxacin and pefloxacin on growth of normal human hematopoietic progenitor cells and on leukemic cell lines: E. Somekh, et al.; J. Pharmacol. Exp. Ther. 248, 415 (1989) Binding interactions of pefloxacin mesylate with bovine lactoferrin and human serum albumin: J.C. Fan, et al.; J. Zhejiang Univ. Sci. B. 7, 452 (2006) Spectrophotometric determination of pefloxacin mesylate in pharmaceuticals: K. Basavaiah, et al.; Acta Pharm. 57, 221 (2007)
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