PDK1/Akt/Flt Dual Pathway Inhibitor is a cell-permeable compound that selectively induces apoptosis in AML (Acute Myelogenous Leukemia) with little effect on normal CD34+ AML progenitor cells. Directly inhibit both PDK1 and Akt activities in in vitro kinase assays in a dose-dependent manner and block cellular phosphorylation of Akt at both Ser473 and Thr308. PDK1/Akt/Flt Dual Pathway Inhibitor's dual inhibition nature against both PDK1/Akt and Flt3/PIM signaling pathways allows effective elimination of AML cells that are otherwise resistant to inhibitors that target only the PDK1/Akt pathway.
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