PDK1/Akt/Flt Dual Pathway InhibitorA cell-permeable compound that selectively induces apoptosis

PDK1/Akt/Flt Dual Pathway Inhibitor (CAS 331253-86-2)

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Synonym: 6H-Indeno[1,2-e]tetrazolo[1,5-b][1,2,4]triazin-6-one & 10H-Indeno[2,1-e]tetrazolo[1,5-b][1,2,4]triazin-10-one
Application: A cell-permeable compound that selectively induces apoptosis
CAS Number: 331253-86-2
Molecular Weight: 224.18
Molecular Formula: C10H4N6O
* Refer to Certificate of Analysis for lot specific data (including water content).
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PDK1/Akt/Flt Dual Pathway Inhibitor is a cell-permeable compound that selectively induces apoptosis in AML (Acute Myelogenous Leukemia) with little effect on normal CD34+ AML progenitor cells. Directly inhibit both PDK1 and Akt activities in in vitro kinase assays in a dose-dependent manner and block cellular phosphorylation of Akt at both Ser473 and Thr308. PDK1/Akt/Flt Dual Pathway Inhibitor's dual inhibition nature against both PDK1/Akt and Flt3/PIM signaling pathways allows effective elimination of AML cells that are otherwise resistant to inhibitors that target only the PDK1/Akt pathway.


References

Zeng, Z., et al. 2006. Cancer Res. 66, 3737. Koul, D., et al. 2006. Mol. Cancer Ther. 5, 637. Mandal. M., et al. 2006. Oral Oncol. 42, 430. Mandal. M., et al. 2005. Br. J. Cancer 92, 1899.

Physical State :
Solid
Solubility :
Solubility: DMSO (10 mg/ml)
Storage :
Store at 4° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
PubChem CID :
5113385
SMILES :
C1=CC=C2C(=C1)C3=NC4=NN=NN4N=C3C2=O

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Certificate of Analysis

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