PDDHV is a resiniferatoxin (RTX)-type phorboid vanilloid with capsaicin-like selectivity for VR1, shown to evoke Ca2+ uptake in rat dorsal root ganglion neurons with an EC50 = 70nM, while inhibiting RTX binding to said neurons with a much lower potency (Ki > 10,000 nM). The ability of PDDHV to elicit Ca2+ uptake at sub-micromolar concentrations, while having a much lower binding affinity to rat dorsal root ganglion membranes, represents more than 100 times capsaicin-like pharmacology. PDDHV provides a tool to explore this capsaicin-like, vanilloid pharmacology.
1. Szallasi, A., et al. 1999. Br. J. Pharmacol. 128: 428-434. PMID: 10510454
Soluble in DMSO, ethanol, methanol, and chloroform. Insoluble in water.
Store at -20° C
850.89° C at 760 mmHg (Predicted)
1.19 g/cm3 (Predicted)
n20D 1.57 (Predicted)
Evoke Ca2+ uptake: EC5050 = 70 nM (rat)
TRPV1: Ki= 60 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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Rated 5 out of
Alvarez et alAlvarez et al. (PubMed ID 17008604) used PDDHV, a vanilloid transient receptor potential channel (TRPV1) antagonist, to study alveolar response to calcium concentration. -SCBT Publication Review
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