PDDHVA RTX-type phorboid vanilloid with capsaicin-like selectivity for VR1 but with 100 times the potency

PDDHV (CAS 179469-40-0)

PDDHV | CAS 179469-40-0 is rated 5.0 out of 5 by 1.
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Synonym: Phorbol 12,13-didecanoate 20-homovanillate
Application: A RTX-type phorboid vanilloid with capsaicin-like selectivity for VR1 but with 100 times the potency
CAS Number: 179469-40-0
Molecular Weight: 837.09
Molecular Formula: C49H72O11
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* Refer to Certificate of Analysis for lot specific data (including water content).
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PDDHV is a resiniferatoxin (RTX)-type phorboid vanilloid with capsaicin-like selectivity for VR1, shown to evoke Ca2+ uptake in rat dorsal root ganglion neurons with an EC50 = 70nM, while inhibiting RTX binding to said neurons with a much lower potency (Ki > 10,000 nM). The ability of PDDHV to elicit Ca2+ uptake at sub-micromolar concentrations, while having a much lower binding affinity to rat dorsal root ganglion membranes, represents more than 100 times capsaicin-like pharmacology. PDDHV provides a tool to explore this capsaicin-like, vanilloid pharmacology.


References

1. Szallasi, A., et al. 1999. Br. J. Pharmacol. 128: 428-434. PMID: 10510454

Physical State :
Solid
Solubility :
Soluble in DMSO, ethanol, methanol, and chloroform. Insoluble in water.
Storage :
Store at -20° C
Boiling Point :
850.89° C at 760 mmHg (Predicted)
Density :
1.19 g/cm3 (Predicted)
Refractive Index :
n20D 1.57 (Predicted)
IC50 :
Evoke Ca2+ uptake: EC5050 = 70 nM (rat)
Ki Data :
TRPV1: Ki= 60 nM
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
10653082
MDL Number :
MFCD02684413
SMILES :
CCCCCCCCCC(=O)O[C@@H]1[C@H]([C@]2([C@@H](C=C(C[C@]3([C@H]2C=C(C3=O)C)O)COC(=O)CC4=CC(=C(C=C4)O)OC)[C@H]5[C@@]1(C5(C)C)OC(=O)CCCCCCCCC)O)C

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Certificate of Analysis

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PDDHV  Product Citations

See how others have used PDDHV. Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 17008604  Alvarez, DF. et al. 2006. Circ. Res. 99: 988-995.

PMID: # 10510454  Szallasi, A. et al. 1999. Br. J. Pharmacol. 128: 428-434.

Citations 1 to 2 of 2 total
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Rated 5 out of 5 by from Alvarez et al Alvarez et al. (PubMed ID 17008604) used PDDHV, a vanilloid transient receptor potential channel (TRPV1) antagonist, to study alveolar response to calcium concentration. -SCBT Publication Review
Date published: 2015-05-31
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